摘要
【目的】为狼疮性肾炎(1upus nephritis,LN)的治疗以及疗效评价提供新的思路和方法。【方法】将23例病情尚未得到有效控制的LN患者,以昆母汤(由昆明山海棠和益母草组成)联合激素治疗,前后对照观察系统性红斑狼疮病情活动指标(SLEDAI)评分,检测尿蛋白及转化生长因子-β1(TGF-β1)、巨噬细胞炎性蛋白-1ɑ(MIP-1ɑ)、中性粒细胞明胶酶相关性脂质运载蛋白(NGAL)等尿液生物学标记物水平变化,并评价其安全性。【结果】(1)治疗12周后,患者SLEDAI评分较治疗前显著下降(P<0.05)。(2)治疗12周后,患者24 h尿蛋白及尿TGF-β1、MIP-1α、NGAL水平均较治疗前显著下降(P<0.05)。(3)治疗期间,有3例患者出现不良反应,主要表现为肝、肾功能异常和月经量减少。【结论】昆母汤联合激素治疗LN可以降低患者的疾病活动度,阻滞肾纤维化进程,减轻活动性炎症损害程度,缓解细胞损伤,改善实验室指标,用药安全性好。
Objective To explore a new method for the evaluation of therapeutic effect for 1upus nephritis（LN）.Methods Twenty-three active LN were treated with glucocorticoid plus Kunmu Decoction, composed of Tripterygium hypoglaucum（Levl.） Hutch and Herba Leonuri. By self-controlled trial, we observed the scores of systemic lupus erythematosus disease activity index（ SLEDAI）, detected the biomarker levels of urine protein, transforming growth factor-β1（ TGF-β1）, macrophage inflammatory protein-1α（ MIP-1α）, and neutrophilic granulocyte gelatinase associated lipid transporter（NGAL）, and evaluated the safety. Results（1）After treatment for 12 weeks, the scores of SLEDAI were much decreased（P〈0.05）.（2） After treatment for12 weeks, 24-hour urine protein and urine TGF-β1, MIP-1α and NGAL levels were decreased compared with those before treatment（ P〈0.05）.（ 3） During the treatment, There were 3 cases of adverse events, showing as hepatic and renal function disorder and the decrease of menstrual blood volume. Conclusion Kunmu Decoction plus glucocorticoid is effective and safe for the treatment of LN by reducing disease activity, blocking renal fibrosis process, alleviating the degree of active inflammatory damage, relieving cell damage, and improving laboratory indicators.
出处
《广州中医药大学学报》
CAS
2015年第2期212-215,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
作者简介
作者简介：刘渊彬（1987-），女，硕士研究生；E-mail：287236327@qq.com
通讯作者：关彤（1968-），男，医学博士，主任中医师；E-mail：2323438176@qq．com
