摘要
目的:通过观察高氧下大鼠肺、肠黏膜细胞因子IL-1β,IL-2、IL-6、TNF-α含量的变化,探讨"肺与大肠相表里"的生物学机制。方法:实验设立正常空气组、高氧组(吸入40%浓度氧),比较2组肺泡灌洗液、肠黏膜灌洗液中IL-1β,IL-2、IL-6、TNF-α的含量。结果:造模5 d后,大鼠肺泡灌洗液和肠黏膜灌洗液中的IL-1β、IL-2、IL-6含量均较正常空气组呈现明显下降(P<0.05);大鼠肺泡灌洗液及肠黏膜灌洗液的TNF-α也表现为较正常空气组下降的趋势(P>0.05)。结论:肺肠之间在黏膜免疫方面具有同步性,这可能是肺与大肠表里关系的重要的生物学基础。
Objective：To observe the hyperoxia stimulus to lung and intestinal mucosa of rats and the changes of the content of cy-tokines IL-1beta,IL-2,IL-6,TNF alpha,so as to explore the biological mechanisms of‘Lung and Large Intestine being interior-ex-teriorly related’ .Methods：The experiment set up two groups-normal group and the hyperoxia one-which the oxygen concentration was 40%.The content of IL-1beta,IL-2,IL-6,the TNF alpha of Bronchoalveolar lavage fluid and intestinal mucosa lavage fluid was compared.Results：After 5 days,compared with normal group,IL-1beta,IL-2 and IL-6 levels of both the Bronchoalveolar lavage flu-id and intestinal mucosa lavage fluid dropped significantly （P〈0.05）,and TNF alpha of both the Bronchoalveolar lavage fluid and Intestinal mucosa lavage fluid showed a trend of decline.Conclusion：Lung and Large Intestine have the synchronicity from the per-spective of mucosal immunity,and it may be the important biological basis for lung and large intestine exterior-interior relationship.
出处
《世界中医药》
CAS
2015年第1期80-82,85,共4页
World Chinese Medicine
基金
国家重点基础研究发展计划(973计划)资助项目(编号:2009CB522706)
关键词
肺与大肠相表里
高氧
细胞因子
Lung and Large Intestine being interior-exteriorly related
Hyperoxia
Cytokines
作者简介
韩俊阁，女，在读博士，研究方向：四时五脏阴阳的文献整理和实验研究，E-mail：hanjunge@163．com
通信作者：郭霞珍，女，教授，博士研究生导师，E-mail：guoxiazhen@126．com
