摘要
目的:建立肺病、肠病、肺肠合病大鼠病理模型,通过观察其血清TNF-αI、L-1含量情况,探索"肺与大肠相表里"相关病理机制。方法:实验设正常对照组、肺病组(过敏性哮喘)、肠病组(便秘)和肺肠合病组(过敏性哮喘合便秘)共4组。结果:与正常对照组比较,肺病组、肠病组、肺肠合病组大鼠血清TNF-αI、L-1含量均呈显著性差异(P<0.01);与肺病组比较,肺肠合病组大鼠血清TNF-αI、L-1含量呈显著性差异(P<0.01);与肠病组比较,肺肠合病组大鼠血清TNF-αI、L-1含量呈显著性差异(P<0.01)。结论:肺肠合病组大鼠血清TNF-αI、L-1含量均明显高于肺病组及肠病组,证实TNF-αI、L-1可能是肺与大肠相关的共同物质基础,为"肺与大肠相表里"理论提供一定的现代医学实验依据。
Objective ： To establish lung disease rat model, intestine disease model and lung - intestine disease model, through the observation on serum TNF - α and IL - 1 contents changes to explore the pathology mechanism of interior - exterior relation-ship between lung and large intestine. Methods ： There are four groups ： normal control group, lung disease group （ irritablity asthma） ,intestine disease group（constipation） and lung-intestine disease group（irritablity asthma and constipation）. Results：Compared with normal control group, serum TNF - α and IL - 1 contents in lung disease group, intestine disease group and lung - intestine disease group were significantly different（ P 〈 0. 01 ）. Compared with lung disease group, serum TNF -α and IL - 1 con- tents in lung-intestine disease group were significantly different（P 〈 0. 01 ）. Compared with intestine disease group, serum TNF -α and IL - 1 contents in lung - intestine disease group were significantly different（ P 〈 0. 01 ）. Conclusion：Serum TNF - α and IL - 1 contents in lung - intestine disease group are obviously higher than that in disease group and intestine group. It is concluded that TNF - α and IL - 1 may be the basis of the relationship between lung and large intestine, providing modem medical basis.
出处
《辽宁中医杂志》
CAS
2012年第1期153-154,共2页
Liaoning Journal of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)资助项目(2009CB522706)
关键词
肺与大肠相表里
TNF-Α
IL-1
哮喘
便秘
interior - exterior relationship between lung and large intestine
TNF - α
IL - 1
asthma
constipation
作者简介
惠毅（1982-），女，陕西西安人，博士研究生，研究方向：中医药对感染性疾病的防治。
通讯作者：杨宇（1953-），男，四川成都人，教授，博士研究生导师，研究方向：中医药对感染性疾病的防治。
