摘要
“肺与大肠相表里”是中医学理论的基本内容,其核心是肺与大肠作为一个整体而相互关联。近代生物学研究显示:肠道微生态与呼吸道微生态相互影响,肠道微生物组稳态失衡进而导致呼吸道微生态组稳态失衡,即“肠病及肺”,故中医临床往往以“肺肠同治”法进行治疗。西医研究结果显示糖尿病患者往往合并肠道微生物组稳态失衡,而肺作为一个毛细血管密集的脏器,是糖尿病的重要靶器官。因此通过研究近年来的文献资料,结合肠道微生物组这一热点,探讨“肺与大肠相表里”在糖尿病肺损伤中的生物学基础,进而丰富中医藏象理论内涵,为防治糖尿病肺损伤提供新思路。
Theory of exterior and interior relation of lung and large intestine is the foundation of traditional Chinese medicine(TCM)theory,and its core theory is to consider lung and large intestine are correlated as a whole.The imbalance of gut microbiome can induce the imbalance of respiratory tract microbiome,as"large intestinal diseases lead to pulmonary disease",so we can adopt the TCM method to treat the large intestinal and pulmonary disease at the same time.Modern medicine shows that the patients with diabetes mellitus often associate with homeostasis imbalance in intestinal microecology group;nevertheless,lung,as an organ with rich capillariesis,is an important target organ of diabetes mellitus(DM).Therefore,the biology basis of"theory of exterior and interior relation of lung and large intestine"in diabetic lung injury is discussed by studying recent literature and combining with the heated discussion of intestinal microecology group,so as to enrich the viscera and manifestations theoretical connotation of TCM and provide new ideas for the prevention and treatment of diabetic Pulmonary Injury.
作者
邰贺
李顺民
陈剑平
鲁宇轩
孟宪生
姜晓琳
Tai He;Li Shunmin;Chen Jianping;Lu Yuxuan;Meng Xiansheng;Jiang Xiaolin(College of pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116000,China;The Fourth of Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Shenzhen 518033,China;Key Laboratory of Hospital Chinese Medicine Preparation,Shenzhen 518033,China;Collage of basic medical science,Chinese Capital Medical University,Beijing 100069,China;Department of Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory in Liaoning Traditional Chinese Medicine University,Shenyang 110847,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2022年第8期2932-2937,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
中国博士后科学基金会面上项目(2022MD713765):基于ASK1/JNK信号通路探讨益气养阴法对T2DM大鼠肺功能保护作用的分子学机制,负责人:邰贺
关键词
肺与大肠相表里
肺肠微生物组
糖尿病
肺损伤
Exterior and interior relation of lung and large intestine
Gut microbiome
Diabetes mellitus
Lung damage
作者简介
通讯作者:姜晓琳,副主任医师,高级实验师,医学博士,主要研究方向:中西医结合基础理论方面的研究;通讯作者:孟宪生,主任药师,教授,医学博士,博士生导师,主要研究方向:中药复方药效物质基础的研究
