摘要
酸枣仁是公认的大宗中药品种之一,具有养心安神、补肝、敛汗生津之功效,是中医治疗失眠的首选药物。目前,酸枣仁化学成分研究较为清晰,其主要化学成分为黄酮类、皂苷类、生物碱类和三萜酸类等,结构丰富多样。酸枣仁化学成分的多样性决定了其生物学活性和药理作用的多样性,同时导致其药动学复杂的特性。通过对国内外文献分析与总结,梳理了酸枣仁化学成分(黄酮类、皂苷类)的药动学参数、吸收情况、组织分布特征和代谢研究成果(肠道菌群代谢转化、肝微粒体代谢转化、体内代谢转化),以期从体内过程的角度进行深度发掘和分析,为酸枣仁药效物质发现提供新的研究方向,同时为酸枣仁质量标志物的筛选和确定提供参考。
Ziziphi Spinosae Semen(ZSS),one of the major traditional Chinese medicine varieties,has been used as a sedative medicine in China for thousands of years.The classical application of ZSS is nourishing heart and tranquilizing mind,tonifying the liver,arresting the sweat and promoting the production of the body fluid.Up to now,extensive chemical studies have also been conducted,suggesting the presence of alkaloids,flavonoids,saponins,and triterpene acids.Given the chemical diversity of ZSS,it is generally considered that the biological activity and pharmacological effect were accomplished by an array of phytochemicals.Due to complicated chemical composition of ZSS,compounds can be absorbed into circulation and then converted into even more metabolites.This review summarizes the recent advances in pharmacokinetics,absorption,and distribution,as well as biotransformation and/or metabolism of chemical compounds from ZSS,which might greatly contribute to supply the research target and scientific basis in clarifying the effective substance basis and the quality marker(Q-marker) of ZSS.
作者
闫艳
张敏
崔小芳
张福生
高晓霞
郭旭东
杜晨晖
秦雪梅
YAN Yan;ZHANG Min;CUI Xiao-fang;ZHANG Fu-sheng;GAO Xiao-xia;GUO Xu-dong;DUChen-hui;QIN Xue-mei(Modem Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;School of Traditional Chinese Materia Medica,Shanxi University of Chinese Medicine,Taiyuan 030619,China;College of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China;Tianjin High School,Tianjin 300100,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第2期299-309,共11页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金青年基金项目(81603289)
国家自然科学基金青年基金项目(81603251)
山西省科技攻关计划-振东专项(2014ZD0306
2016ZD0105
2016ZD0104)
山西省基础研究计划项目自然科学基金项目(2015011105)
地产中药功效物质研究与利用山西省重点实验室(201605D111004)
山西省研究生联合培养基地人才培养项目(2017JD01)
关键词
酸枣仁
药动学
代谢
药效物质
质量标志物
Ziziphi Spinosae Semen
pharmacokinetics
metabolism
effective and active compounds
quality marker (Q-marker)
作者简介
闫艳,博士,讲师,研究方向为中药体内过程研究及中药质量控制。Tel:(0351)7018379,E-mail:yanyan520@sxu.edu.cn;通信作者:杜晨晖,副教授,研究方向为中药药效物质基础。Tel:(0351)3179979,E-mail:13653412562@163.com;通信作者:秦雪梅,教授,研究方向为中医药代谢组学。Tel:(0351)7018379,E-mail:qinxm@sxu.edu.cn.
