摘要
目的：探讨脂质过氧化作用在＋Ｇｚ所致的咬肌损伤中的作用。方法：体重为２００－２５０克雄性Ｗｉｓｔａｒ大鼠 １４只随机分成 Ａ组和 Ｂ组，各 ７只。Ａ组用特制的固定装置固定 ５ｍｉｎ，Ｂ组固定于动物离心机的转臂上，加速度曲线为梯形，Ｇ值增长率约为０．５Ｇ／ｓ，＋１０Ｇｚ峰值持续时间为３０ｓ，间隔＋１Ｇｚ ６０ｓ，连续５ｔｉｍｅｓ／ｄ，４ｄ／ｗｋ，共３周。离心后测定咬肌匀浆中丙二醛（ＭＤＡ）和超氧化物歧化酶（ＳＯＤ）含量。结果：与Ａ组相比，Ｂ组咬肌组织匀浆中 ＭＤＡ含量均明显升高，而 ＳＯＤ含量未见变化。结论：增多的自由基与机体消除自由基能力之间平衡失调在咬肌发生病理改变过程中起一定作用。
Objective: To study the effects of lipid peroxidation on masseter musscles in rats after repeated +Gz stress. Methods: 14 male Wistar rats were randomly divided into 2 groups: group A and group B. Group A was borne for 5 minutes with rat-kept device. Group B was-repeatedly exposed +10Gz (each for 30s, onset rate about 0.5G/s, 5 times/d with +lGz 1 minute intervals, 4d/wk, 3 weeks in total). The content of MDA and SOD in masseter musscles homogenate were determined. Results: Compared the group A, in group B the levels of MDA in masseter were increased, but SOD were not changed. Conclusions: This imbalance between MDA and SOD may play a role at a certain degree in the process that repeated +Gz stress caused masseter musscles injury.
出处
《口腔颌面修复学杂志》
2001年第3期178-180,共3页
Chinese Journal of Prosthodontics
基金
军队95医药卫生科研课题编号98M057
