摘要
目的 :通过离体和整体实验研究大鼠及人的肠道内细菌对人参皂苷Rg1的代谢作用。方法 :用薄层层析及电喷雾质谱检测Rg1的代谢产物。结果 :Rg1在大鼠体内被代谢成一对同分异构体 (Rh1及F1)及苷元 [2 0(S)Protopanaxatriol,Ppt]。但在人的肠道内 ,则代谢物为Rh1及苷元。结论 :Rg1在人和大鼠肠内菌作用下均被代谢 ,但沿不同的代谢途径进行代谢。在大鼠体内 ,代谢模式为 :Rg1Rh1(F1)Ppt ;在人体内 ,代谢模式为Rg1Rh1Ppt。
Objective:The decomposition of Ginsenoside Rg 1 (Rg 1) by intestinal bacteria in rats or human was investigated both in vitro and in vivo. Method: The decompositions were investigated by means of thin-layer chromatography and Electron spurt ion mass.Result:It was found that Rg 1 was converted into two metabolites [Rh 1 and 20(S)-protopanaxatriol(20S-Ppt)] by human intestinal bacteria in vitro, while three compounds [Rh 1, F 1, and 20(S)-Ppt] were detected in rat intestinal bacteria metabolism in vitro and in vivo. Conclusion:The decomposition and/or metabolism of Rg1 in rat and human digestive tract was confirmed. The mode of metabolism in rat is Rg 1 Rh 1 (F 1)Ppt, while in human it is Rg 1Rh 1Ppt.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2001年第3期188-190,共3页
China Journal of Chinese Materia Medica
基金
国家自然科学基金资助课题! (3 95 70 861)
关键词
人参皂苷RG1
人参皂苷RH1
肠内菌群
电喷雾质谱
薄层层析
ginsenoside Rg 1
ginsenoside Rh 1
intestinal bacteria
Electron spurt ion mass
thin layer chromatography
