摘要
目的观察人参皂苷Rg1和Rh1对树突状细胞(Dendriticcell,DC)表面分子CD25、HLA-DR、CD44、ICAM-1、CD11c及E-selectin表达的影响。方法用不同浓度的Rg1和Rh1分别加入成熟DC中,刺激一定时间后,用免疫组化法观察,并用图像分析法分析结果。结果除E-selectin外,Rg1和Rh1均可不同程度地促进HLA-DR、CD25、CD11c、CD44和ICAM-1的表达。结论Rg1、Rh1可增强DC表面促进T细胞活化的第一、二类信号系统分子的表达,提高其抗原递呈能力,并促进DC-T细胞簇的形成而活化初始T细胞。
Objective：To test the effect of Ginsenoside Rg1 and Rh1 on the expression of CD25, HLA-DR, CD44, ICAM-1, CD11c and E-selectin on the surface of dendritic cell（DC）. Methods：Mature DCs were treated with different doses of Rg1 and Rh1. Certain time later, the expression of adhesion molecular was detected with immunohistochemical method and the results were recorded with imaging data. Results： Except for E-selectin, both of Rgl and Rg1 could increase the expression of HLA-DR, CD25, CD11 c, CD44 and ICAM-1 on DCs. Concluslon：Expression increase of surface molecular, including in two signals required by T ceU activation, stimulated by Rgl and Rill, is propitious to the formation of DC- T cell cluster that would enhance the antigen-presenting function of DC.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2007年第1期46-48,52,共4页
Chinese Journal of Immunology
基金
国家自然科学基金(39870949)资助
作者简介
王毅（1971年-），女，免疫学博士后，主要从事中药免疫调节机制研究，现在中国中医科学院工作；
通讯作者及指导教师：邱全瑛（1936年-），女，教授，博士生导师，主要从事中药免疫调节机制研究，E-mail：quanyingq@yahoo．com．cn。
