摘要
目的了解强直性脊柱炎(ankylosing spondylitis,AS)患者的生存质量现状,探索影响AS患者生存质量的因素,为指导临床治疗,评价预后提供依据。方法整群抽取2010年6月～2011年6月年安徽医科大学第一附属医院风湿科门诊确诊的AS患者129人,采用SF-36量表对这些患者的生存质量进行评价,并对影响AS患者生存质量的因素进行分析。结果与一般人群相比,AS患者的生存质量下降,与活动性AS患者组bath AS疾病活动性指数(bath AS disease activity index,BASDAI)≥4相比稳定性强直性脊柱炎患者组(BASDAI<4)的各维度得分除社会功能维度外,其余均升高,差异均有统计学意义(均有P<0.05);功能状态较好bath AS功能指数(bath ASfunctional index,BASFI)<5的AS患者与功能状态较差(BASFI≥5)的AS患者相比,前者的SF-36得分除社会功能维度外,其余均高于后者,差异均有统计学意义(均有P<0.05);多因素分析结果显示对治疗前景的态度、BASDAI、BASFI可能影响AS患者的生存质量。结论 AS患者的生存质量与一般人群相比下降。针对影响AS患者生存质量的因素进行宣传教育及积极治疗对改善AS患者的生存质量至关重要。
Objective To understand the status of the quality of life of patients with ankylosing spondylitis, and explore the influencing factors of quality of life in AS patients, in order to guide the clinical treatment and provide the prog-nostic evaluation. Methods 129 patients with ankylosing spondylitis were collected from Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University. The quality of life was evaluated by SF-36 scale, and the influencing factors of quality of life were analysed. Results Compared with the general population, quality of life of AS patients was significantly decreased ; compared with the stability AS groups （ BASDAI 〈 4 ）, except social function score, the rest scores of active AS groups （ BASDAI ≥ 4 ） were significantly reduced （ all P 〈 0. 05 ） ; compared to AS patients whose functional status was poor （ BASFI ≥ 5 ） , except social functioning, the rests of SF-36 scores were higher in AS pa-tients whose functional status （ BASFI 〈 5 ） was good （ all P 〈 0. 05 ） ; multivariate analysis showed that treatment pros-pects, BASFI and BASMI might affect the quality of life of patients with AS. Conclusions Compared to the general popu-lation, the quality of life of AS has declined markedly. Publicity, education and active treatment are essential to improve the quality of life of patients with AS.
出处
《中华疾病控制杂志》
CAS
北大核心
2013年第5期384-387,共4页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(30771849
30972530)
安徽省自然科学基金(090413133)
关键词
脊柱炎
强直性
危险因素
流行病学研究
Spondylitis, ankylosing
Risk factors
Epidemiologic studies
作者简介
王笙（1985-），女，山东济宁人，在读硕士研究生。主要研究方向：疾病统计。
【通讯作者】潘发明，E-mail：famingpan@ahmu．edu．cn
