摘要
目的进一步探讨肿瘤坏死因子（tumor necrosis factor，TNF）-α基因启动子－238位点多态性与强直性脊柱炎（ankylosing spondylitis，AS）的相关情况。方法通过中国生物医学文献数据库、中国期刊全文数据库、万方、维普、PubMed、Cochrane Library、Ovid、Wiley Online Library、EBSCO、Elsevier Science Direct、Springer、Goolgescholar数据库检索国内外已发表或未发表TNF—α基因启动子一238位点多态性与AS相关的病例对照研究，采用Meta分析综合定量分析最终纳入的文献。结果17篇文献共纳入1899例患者和2381例对照，Meta分析结果提示在总人群（OR=0．96，95％CI：0．76一1．21，P=0．720）、亚洲人群（OR=1．38，95％6／：0．84～2．24。P=0．200）、非亚洲人群（OR=0．97，95％6／：0．61—1．55，P=0．900）均不能明确TNF—Ot-238位点（GA十AA）vs．GG基因型与AS间存在关联；非亚洲人群（OR：0．40，95％CI：0．08～2．03，P：0．270）均不能明确TNF－α-238位点（GG＋GA）VS．AA基因型与AS间存在关联；在总人群（OR：0．95，95％6／：0．52～1．74，P=0．870）、亚洲人群（OR=1．39，95％6／：0．90～2．14，P=0．140）、非亚洲人群（OR=0．79，95％6／：0．33～1．86，P=0．590）均不能明确TNF—α－238位点GVS．A等位基因多态性与AS间存在关联。结论Meta分析显示总人群、亚洲人群和非亚洲人群TNF—α－238位点各基因型和等位基因多态性与AS间均未显示关联。
Objective To further explore the association of the polymorphism in -238 site of tumor necrosis factor （TNF）-α promoter region with ankylosing spondylitis（AS）. Methods The references between polymorphism in -238 site of TNF-α promoter region with AS were retrieved through Chinese Biomedical Database （ CBM ）, Chinese National Knowl- edge Infrastructure （CNKI） , Wan Fang, Wei Pu, PubMed, Cochrane Library, Ovid, Wiley Online Library, EBSCO, Elsevier Science Direct, Springer, Goolge scholar databases, until September 20, 2013. A recta-analysis was used to systematically analyze the literatures that were included finally. Pooled odds ratios （OR） with 95% confidence intervals （CI） were appropriately derived from random-effects models or fixed-effects models. Results 17 studies were included in the fi- nal meta-analysis, enrolling a total of 1 899 AS cases and 2 381 controls. Subgroup （ Asian and non- Asian） analysis were stratified by ethnieity. The recta-analysis showed that the frequencies of （ GA ＋ AA ） vs. GG genotypes had no statistical difference between AS group and the control group in the global group （ OR =0. 96, 95% CI： 0. 76-1.21, P =0. 720）, in the Asian populations （ OR = 1.38, 95% CI： 0. 84-2. 24, P = 0. 200） and in the non-Asian populations （ OR = 0. 97, 95 % CI： 0. 61-1.55, P = 0. 900）. The analysis also showed that the frequencies of （ GG ＋ GA） vs. AA genotypes had no statistical difference between AS group and the control group in the global group （ OR =0.40, 95% CI： 0. 08-2. 03, P = 0. 270） and in the non-Asian populations （OR =0. 40, 95% CI： 0. 08-2. 03, P =0. 270）. The analysis also showed that the frequencies of G vs. A alleles had no statistical difference between AS group and the control group in the global group （0R=0.95, 95% CI： 0.52-1.74, P =0.870）, in the Asian populations （OR = 1.39, 95% CI： 0.90-2. 14, P = 0. 140） and in the non-Asian populations （ OR = 0. 79, 95% CI： 0. 33-1.86, P = 0. 590）. Conclusions The meta-anal- ysis revealed that the TNF-ct -238 G/A polymorphisms may not be associated with AS. However, the meta-analysis needs to be confirmed by more studies with larger population of various ethnicity and stratified by clinical characteristics in the future.
出处
《中华疾病控制杂志》
CAS
北大核心
2014年第3期194-199,共6页
Chinese Journal of Disease Control & Prevention
基金
安徽省自然科学基金(110512158)
关键词
脊柱炎
强直性
肿瘤坏死因子Α
多态性
单核苷酸
META分析
Spondylitis, ankylosing
Tumor necrosis factor-alpha
Polymorphism, single nueleotide
Meta analysis
作者简介
陈银河（1986-），男，安徽阜南人，在读硕士研究生。主要研究方向：脊柱外科。
【通讯作者】申才良，E-mail：shencailiangl616@163．com
