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强直性脊柱炎患者听力损害的影响因素分析

Factors realated to the hearing loss in ankylosing spondylitis patients
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摘要 【摘要】目的通过对AS患者听力功能的评估,探讨其听力损害的影响因素。方法本组AS患者40例,其中男性39例,女性1例,平均年龄(36_+11)岁。采用纯音听阈测定、鼓室导抗图和畸变产物耳声发射(DPOAE)评估患者听力功能,同时收集患者的临床资料(包括年龄、发病年龄、病程和后凸畸形病史)、影像学资料(包括后凸Cobb角)、实验室检查(包括ESR及CRP)、生活质量评估表[包括Oswestry功能障碍指数(ODI)、BASDAI及BASFI]。采用Spearman相关系数分析As患者听力损害的相关因素。结果本组患者共80耳,其中纯音听阈异常52耳(65%),250、500、1000、2000、4000、8000Hz频率的纯音听阈分别为(28±7)、(28±7)、(27±7)、(25±7)、(31±16)、(25±16)dB;鼓室导抗图示A型71耳(89%),B型6耳(8%),C型3耳(4%);DPOAE示耳蜗功能受损62耳(78%),500、1000、2000、4000、6000、8000Hz频率的DPOAE分别为(1.2±9.7)、(6.6±8.6)、(6.2±8.4)、(5.O±8.3)、(8.4±7.9)、(8.6±11.9)dB。Spearman相关分析发现,AS患者纯音听阈损害与其年龄、发病年龄及DPOAE有相关性(P均〈0.05),而与病程、后凸病史、ESR、CRP、后凸Cobb角、ODI、BASDAI及BASFI无显著相关性(P均〉0.05)。结论年龄、发病年龄及耳蜗功能为AS患者听力损害主要影响因素。 Objective To investigate hearing loss in ankylosing spondylitis (AS) patients and analyze the related factors. Methods Forty AS patients (39 males and 1 female) were included into this study. The average age was 36±11 years old. Hearing function was evaluated by the pure tone air and bone conduction threshold testing, tympanogram and distortion production otoacoustic emissions (DPOAE). The quality of life was assessed by the Oswetry Disability Index (ODI), Bath ankylosing spondylitis disease activity index (BASDAI) and Bath ankylosing spondylitis functional index (BASFI). The clinical data,erythrocyte sedimen- tation rate (ESR), C reactive protein (CRP) and global kyphotic Cobb angle (GK) were also recorded. In addition, correlation between heating loss and the possible related factors was analyzed using the Spearman's coefficient analysis. Results Heating loss was found in 52 of 80 ears (65%). The mean pure tone thresholds of 250, 500, 1 000, 2 000, 4 000 and 8 000 Hz frequencies were (28±7), (28±7), (27±7), (25±7), (31±16), (25±16) dB, respectively. Types A, B and C tympanograms were observed in 71(89%), 6(8%) and 3 (4%) ears. In addition, the cochlear function impairment was found in 62 ears. The DPOAE measu- rements of 500, 1 000, 2 000, 4 000, 6 000, 8 000 Hz frequencies were (l.2±9.7), (6.6±8.6), (6.2±8.4), ( 5.0±8.3 ), ( 8.4±7.9 ), ( 8.6±1 1.9 ) dB, respectively. Significant correlation was observed between heating loss and age, age of onset and DPOAE (all P〈0.05), while there was no correlation between heating loss and disease duration, kyphotie history, GK, ESR, CRP, ODI, BASDAI and BASFI (all P〉0.05). Conclusion Heating loss is a common problem in AS patients with the prevalence 65%, and it is correlated with age, age of disease onset and the cochlear function.
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2014年第2期118-121,共4页 Chinese Journal of Rheumatology
基金 江苏省自然科学基金,江苏省临床医学中心资助项目,南京市医学科学发展重点项目
关键词 脊柱炎 强直性 听力丧失 影响因素 畸变产物耳声发射 Spondylitis, Ankylosing Heating loss Associated factors Distortion production otoacousticemissions
作者简介 通信作者:钱邦平,Email:qianbangping@163.com
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参考文献18

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