摘要
目的研究肿节风全草中酚酸类化学成分。方法利用硅胶柱色谱、凝胶柱色谱、开放ODS柱色谱及制备液相等分离技术,通过理化性质和波谱数据分析进行结构鉴定。结果从肿节风70%乙醇提取物中共分离出15个酚酸类成分,其结构鉴定为原儿茶酸(1),咖啡酸(2),5-O-caffeoylshikimic acid(3),4-O-caffeoyl-shikimic acid(4),3-O-caffeoylshikimic acid(5),迷迭香酸(6),迷迭香酸甲酯(7),迷迭香酸-4-O-β-D-葡萄糖(8),3-O-咖啡酰基奎宁酸(9),5-O-咖啡酰基奎宁酸(10),4-O-咖啡酰基奎宁酸(11),3-甲氧基-4-羟基苯甲酸(12),丁香酸(13),咖啡酸乙酯(14),vinyl caffeate(15)。结论化合物4,5,10,14,15为该属内首次分离得到,其中化合物5核磁数据为首次报道。
Objective To study the phenolic acid constituents from the whole plant of Sarcandra glabra. Methods Silica gel column chromatography, Sephadex LH-20, reverse phase ODS column chromatography and preparative HPLC were used to isolate the compounds whose structures were elucidated based on their physical characteristics and spectroscopic data. Results Fifteen penolic compounds were isolated from 70 % ethyl alcohol extrat of Sarcandra glabra, and they were identified as protocatechuic acid（l）, caffeic acid（2）, 5-O-caffeoylshikimic acid（3）, 4-0- caffeoylshikimic acid （4）, 3-O-caffeoylshikimic acid （5）, rosmarinic acid （6）, rosmarinic acid methyl ester（7）, rosmarinic acid 4-O-B-D-glucopyrannoside （8）, 3-O-caffeoylquinic acid（9）, 5-O-caffeoylquinic acid （10）, 4-O- eaffeoylquinic aeid（ll）, 3-methoxy-4-hydroxybenzoic acid（12）, caryophyllic acid（13）, caffeic acid ethyl ester （14）, vinyl caffeate（15）, respectively. Conclusion Compounds 4, 5, 10, 14 and 15 have been isolated from this genus for the first time, and the NMR data of compound 5 is firstly reported.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2012年第3期295-298,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省中医药管理局课题(20111208)
关键词
肿节风
化学成分
酚酸
Sarcandra glabra
Chemical constituents
Phenolic acids
作者简介
作者简介：黎雄，男，博士，研究方向：中药活性成分研究。Email：youren1994@yahoo．com．cn。
通讯作者：曾星，研究员，博导，研究方向：中药免疫学研究。Email：zengxing-china@163．com。
