摘要
目的:检测妊娠期高血压疾病患者血浆中纤维连接蛋白(FN)、肌酐(Cr)、尿素氮(BUN)及尿蛋白水平的变化,以探求各指标在评价妊娠期高血压疾病病情发展及肾脏功能损伤中的作用。方法:59例妊娠期高血压疾病患者,选择正常非妊娠妇女22例及正常孕晚期妇女35例作为对照组,检测血浆中FN、Cr、BUN及尿蛋白水平进行统计分析。结果:FN:妊娠期高血压疾病组、轻度子痫前期组及重度子痫前期/子痫组较正常孕晚期组增高,差异有统计学意义(P<0.05),且随着病情的发展,改变更加明显;随尿蛋白的增加,FN有增加趋势。Cr、BUN:妊娠期高血压疾病组及重度子痫前期/子痫组较正常孕晚期组增高;轻度子痫前期组与重度子痫前期/子痫组比较,差异有统计学意义(P<0.01)。正常孕晚期组较正常非孕组Cr水平降低(P<0.05)。结论:FN、Cr、BUN及尿蛋白水平在评价妊娠期高血压疾病病情发展及肾功能损伤中有重要的意义;并且对于了解妊娠期高血压疾病病情严重程度有一定的临床意义。
Objective： To investigate the changes of plasma fibronectin （FN）, creatinine （Cr）, blood urea nitrogen （BUN） and proteinuria of gestational hypertensive. Methods： FN, Cr, BUN and proteinuria were examined in 35 normal late - pregnancy women, 22 non - pregnancy women and 59 patients with gestational hypertensive. Results： The FN in patients with gestational hypertensive , in mild pre - eclampsia and in severe pre - eclampsia/eclampsia were higher than normal late - pregnancy women （ P 〈 0. 05 ） ; further more, changes of FN became more apparent with the progression of the disease ; FN increased with the increase of proteinuria. The Cr and BUN in patients with gestational hypertensive and in severe pre - eclampsia/eclampsia were higher than normal late - pregnancy women; There were no obvious changes between mild pre - eclampsia and severe pre - eclampsia/eclampsia （ P 〉 0. 05 ） ; The Cr and BUN in normal late - pregnancy women werelower than normal non- pregnancy women （P 〈 0. 05 ） . Conclusion： The clinical detection of plasma FN, Cr, BUN and proteinuria values appears to be useful in examining progression of gestational hypertensive and dysfunction of kidney.
出处
《中国妇幼保健》
CAS
北大核心
2006年第23期3225-3226,3264,共3页
Maternal and Child Health Care of China
作者简介
通讯作者
