摘要
目的检测妊娠期糖尿病(gestational diabetes mellitus,GDM)患者不同孕龄血清胱抑素C(cystatin C,CysC)及血清尿酸(serum uric acid,UA)水平变化,探讨两者在监测GDM患者发生妊娠期高血压疾病(hypertensive disorder of pregnancy,HDP)的早期病情变化的临床意义。方法选取2010年1月至2012年1月于南海区妇幼保健院进行定期产前检查确诊为GDM的患者114例,将其中妊娠晚期合并HDP患者23例设为A组,无并发症91例设为B组,选取同期90例正常妊娠孕妇为C组,将3组孕妇在孕24～28周、32～34周、38～40周的Cys C、UA检测结果进行比较。结果①3组不同孕龄的血清Cys C比较,差异有统计学意义(F=106.215,P<0.05),且组别与孕龄间存在交互作用(F=26.300,P<0.05),不同孕龄Cys C的检测结果可以用二次方曲线拟合;②3组不同孕龄血清UA检测结果差异有统计学意义(F=21.08,P<0.05),且组别与孕龄间存在交互作用(F=4.11,P<0.05),不同孕龄血清UA的检测结果符合直线趋势拟合。结论血清Cys C与血清UA均与GDM的病情相关,血清CysC联合血清UA的测定在预测GDM合并HDP和肾功能早期损伤有重要意义。
Objective To study clinical significance of serum cystatin C（eystatin C, Cys C） and serum uric acid（ UA ） in the early period of Hypertensive disorder of pregnancy （HDP） complicating C, estational Diabetes Mellitus（GDM） through the changing levels of serum Cys C combined with serum UA detection. Methods Totally 114 cases were prenatal checked - up regularly and clearly diagnosed as GDM from January 2010 to January 2012 in Nanhai Maternal and Child Health Hospital. Among 114 pregnant women with GDM, 23 cases of them complicating HDP were as Group A and the other 91 cases without complications were as Group B. Meanwhile, 90 women with normal pregnancy in the same period were selected for Group C. The levels of serum Cys C and serum UA of all patients in three groups were tested respectively at 24 -- 28 gestational weeks, 32 ~ 34 gestational weeks, 38 ~ 40 gestational weeks and the results were compared. Results （ 1 ） Significant differences of serum Cys C were found among three groups in different periods of pregnancy（ F = 106. 215 ,P 〈 0. 05 ）, and interaction effects between groups and gestational age were found（ F =26. 300 ,P 〈0. 05）. Quadratic curve fitting was described to the indications of the outcome of CysC in different periods of pregnancy. （2） Significant differences of serum UA were found among three groups in different periods of pregnancy（ F = 21.08 ,P 〈 0. 05 ）. Interaction effects between groups and gestational age were found（ F = 4. 11, P 〈 0. 05 ）. Line fitting was described to the indications of serum UA in different gestational age. Conclusion Serum Cys C as well as serum UA was correlated with GMD. This finding may have important implications to predict complicating HDP in GMD and early renal damage by monitoring serum Cys C combined with serum UA.
出处
《中国计划生育和妇产科》
2013年第5期39-42,共4页
Chinese Journal of Family Planning & Gynecotokology
基金
佛山市科技攻关项目(编号:201008147)
关键词
妊娠期糖尿病
妊娠期高血压疾病
血清胱抑素C
血清尿酸
gestational diabetes mellitus
hypertensive disorder of pregnancy
serum Cystatin C
serum uric acid
作者简介
黎凤彩，毕业于中山医科大学，副主任医师，研究方向为妊娠期糖尿病、高危妊娠
