摘要
目的通过测定妊高征患者血尿酸含量,估计妊高征病情发展,监测肾功能早期变化及预测妊娠结局。方法对97例妊高征患者,测定血尿酸、肌酐、尿素氮含量及尿蛋白定性检查,并选择同期正常妊娠孕晚期44例作为对照。结果轻度子痫前期组、重度子痫前期组与子痫组尿酸含量逐渐增加,差异具有显著性意义(P<0.05);尿蛋白++组、尿蛋白+++组与尿蛋白++++组组间比较血尿酸含量差异均无统计学意义(P>0.05)。肌酐、尿素氮在轻度子痫前期组、重度子痫前期组与子痫组有逐渐增加的趋势,但差异均无统计学意义(P>0.05)。围生儿体重与血尿酸含量呈负相关,不同血尿酸含量围生儿死亡率不同,随着血尿酸含量增高围生儿死亡率增加。结论血尿酸可以估计妊高征病情发展,也可作为妊高征肾功能损害比较敏感指标,与围生儿结局密切相关。
Objective： To investigate the changes of serum uric acid in hypertensive disorders complicating pregnancy, in order to estimate the progression of hypertensive disorders complicating pregnancy, to supervise the early changes of kidney function and to forecast prognosis. Methods： Serum uric acid （UA） , creatinine （Cr） , blood urea nitrogen （BUN） and proteinuria were examined in 97 patients with hypertensive disorders complicating pregnancy comparing with 44 normal late - pregnancy women. Results： The level of UA increased with the progression of the disease, the changes had statistical significance （ P 〈 0. 05 ） . There was no significant differences （ P 〉 0. 05） between each proteinuria group about UA, Cr and BUN ; Cr and BUN became increased with the progression of the disease, but there was no statistical changes between them （ P 〉 0. 05 ） . There was negative correlation between UA and weight of perinatal outcome. The mortalitv of perinatal outcome increased along with the increase of the levels of UA. Conclusion： The clinical detection of serum UA values appears to be useful in forecasting the progression of hypertensive disorders complicating pregnancy. And it can be one of sensitive indexes to examine the dysfunction of kidney. UA has relationship with perinatal outcome.
出处
《中国妇幼保健》
CAS
北大核心
2006年第22期3159-3161,共3页
Maternal and Child Health Care of China
关键词
血尿酸
妊高征
肾功能
围生儿死亡率
Serum uric acid
Hypertensive Disorders complicating pregnancy
Kidney function
Perinatal mortality rate
作者简介
通讯作者
