摘要
目的通过数据挖掘及分析探讨中医药治疗良性前列腺增生症(BPH)的临床运用现况及规律.方法系统搜集万方数据和中国知网20余年(2001年~2021年)间中医药治疗BPH的临床研究文献,运用Excel、SPSS 22.0、We-ka3.8、Cytoscape3.6.1对文献中所涉及中药的类别、功效、性味及归经进行规范化数据库管理并通过不同统计学手段予以数据挖掘分析.结果共筛选纳入相关方剂176首,涉及不同中药204味,其中频次≥19的有35味,黄芪、牛膝、穿山甲、茯苓、肉桂频次位列前五;用药以活血化瘀、补虚、利水渗湿类为主,性味多以平温、甘苦辛为主,且归经多为肝、肾、脾;常见药对包括桂枝-茯苓、党参-黄芪、红花-桃仁等;置信度最高的角药为:山茱萸-牡丹皮-茯苓、熟地黄-牡丹皮-茯苓、泽泻-牡丹皮-茯苓等;通过聚类分析和因子分析,共得出8组聚类结果和13对公因子,其中公因子1贡献率为10.648%.结论中医药治疗BPH主要通过益气健脾、温阳补肾、活血利湿祛痰等,侧面反映BPH的发生以脾肾气(阳)虚为本,血瘀、湿阻、痰凝为标,本虚标实为该病的病机特点.
Objective To explore clinical application situation of data mining-based Chinese medicine therapy for benign prostatic hyperplasia(BPH).Methods Clinical research literatures on the treatment of BPH with Chinese medicine were systematically collected from Wanfang Data and China Knowledge Network for more than 20 years(2001-2021),and the categories,efficacy,taste and ascriptions of the Chinese medicines involved in the literature were standardized and managed in a database using Excel,SPSS 22.0,Weka 3.8 and Cytoscape 3.6.1.The data were mined and analyzed.Results A total of176 related prescriptions were screened and included,involving 204 different herbal medicines,of which 35 had a frequency of≥19,Huang Qi,Niu Xi,Fu Ling and Rou Gui ranked among the top five.The main types of medicines used were those that invigorate blood circulation,remove blood stasis,tonify deficiencies,and promoted the flow of water and permeation of dampness,with a mild,sweet,bitter and pungent taste,and the meridians were mostly liver channel,kidney channel and spleen channel.The most common medicine pairs included Gui Zhi-Fu Ling,Dang Shen-Huang Qi,Hong Hua-Tao Ren,etc.;the horned herbs with the highest confidence were:Cornus officinalis-Mudanpi-Fu Ling,Shu Di Huang-Mudanpi-Fu Ling,Ze Xie-Mudanpi-Fu Ling,etc.;Through cluster analysis and factor analysis,8 sets of clustering results and 13 pairs of common factors were obtained.Of which,the contribution of common factor 1 was 10.648%.Conclusion Chinese medicine therapy for BPH mainly focus on benefiting Qi and strengthening the spleen,warming Yang and tonifying the kidney,invigorating blood,promoting diuresis,and dispelling phlegm,etc.It indirectly reflects that the occurrence of BPH is characterized by Qi(Yang)deficiency in the spleen and kidney as the root cause,blood stasis,dampness obstruction and phlegm condensation as the symptoms,and the root deficiency and the symptoms is the characteristics of the disease.
作者
王耀武
郭付祥
杨荣超
温瞿华
李焱风
张富刚
黄文杰
赵凡
张春和
Wang Yaowu;Guo Fuxiang;Yang Rongchao;Wen Quhua;Li Yanfeng;Zhang Fugang;Huang Wenjie;Zhao Fan;Zhang Chunhe(The First Affiliated Hospial of Yunnan University of Traditional Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming,650500,Yunnan,China;Tengchong County Hospital of Traditional Chinese Medicine,Tengchong,679100,Yunnan,China;Nanchang reproductive hospital(Affiliated Hospital of Nanchang Institute of Medical Sciences),Nanchang 330000,China;The Second Affiliated Hospital Zhejiang University School of Medicine,Hangzhou 310000,China;Affiliated Hospital of Nantong University,Nantong 226001,China)
出处
《中国男科学杂志》
CAS
CSCD
2022年第2期28-38,共11页
Chinese Journal of Andrology
基金
国家自然科学基金项目(81860853,81774323)
浙江省中医药科学研究基金项目(A类,2021ZA068)
关键词
中医药
良性前列腺增生(症)
数据挖掘
traditional Chinese Medicine
benign prostatic hyperplasia
data Mining
作者简介
通信作者:赵凡,E-mail:zhaofan@ntu.edu.cn;通信作者:张春和,E-mail:zhangchunhe0426@126.com
