摘要
目的 探讨支气管哮喘儿童呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)水平与过敏原、外周血嗜酸性粒细胞(eosinophil,EOS)计数、血清总IgE的相关性及临床意义。方法 对解放军总医院海南医院2015年6月-2017年6月儿童门诊确诊的79例哮喘儿童病例资料进行回顾性分析。结果 79例哮喘儿童中,≥2种过敏原患者的FeNO值中位数显著高于0 ~ 1种过敏原患者(15 ppb vs 9 ppb,P=0.002)。尘螨过敏患者的FeNO值中位数显著高于非尘螨过敏患者(20 ppb vs 10 ppb,P=0.000);FeNO与EOS、IgE有显著相关性(r=0.480,P=0.000;r=0.450,P=0.000)。结论 支气管哮喘儿童FeNO水平与过敏原、外周血EOS、总IgE具有紧密联系,其在哮喘儿童的诊疗中有重要临床意义。
Objective To investigate the correlation between the expression level of fractional exhaled nitric oxide (FeNO) and allergens,peripheral blood EOS and IgE in asthmatic children and its clinical significance.Methods A retrospective analysis was performed in 79 asthmatic children admitted to Hainan Hospital of Chinese PLA General Hospital from June 2015 to June 2017.Results The FeNO level of allergic patients with 0-1 kind of allergen was lower than that of patients with ≥2 allergens,and the difference was significant (Median:15 ppb vs 9 ppb,P=0.002).Patients with dust mite allergy had higher FeNO level than non-dust mite allergic patients (Median:20 ppb vs 10 ppb,P=0.000).FeNO level had significant correlation with EOS and IgE (r=0.480,P=0.000;r=0.450,P=0.000).Conclusion FeNO is closely corelated to allergens,peripheral blood EOS,total IgE in asthmatic children,which suggests that we should take these into full account in clinical care for asthmatic children.
作者
赵大辉
圣朝军
符余君
解立新
张歆刚
ZHAO Dahui;SHENG Zhaojun;FU Yujun;XIE Lixin;ZHANG Xin'gang(Department of Respiratory,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Respiratory,Hainan Hospital of PLA General Hospital,Sanya 572013,Hainan Province,China)
出处
《解放军医学院学报》
CAS
2020年第2期164-166,195,共4页
Academic Journal of Chinese PLA Medical School
作者简介
赵大辉,女,硕士,主管护师。研究方向:呼吸系统疾病。Email:zhaodahuj07@126.com;通信作者:解立新,男,博士,主任医师,主任。Email:xielx301@126.com
