摘要
目的探究腹腔镜胆囊切除术(LC)对急性胆囊炎患者肝损伤的影响。方法回顾性分析该院行LC治疗(LC组)及开腹胆囊切除术(OC)治疗(OC组)的急性胆囊炎患者各42例,共84例临床资料。记录两组术前、术后1 d、术后5 d血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、C反应蛋白(CRP)水平变化情况,并比较两组术后1个月并发症发生情况。结果两组术后5 d血清AST、ALT水平与术前比较,差异无统计学意义(P>0.05);但两组术后1 d血清AST、ALT水平均明显高于术前及术后5 d(P<0.05);手术前后两组组间血清AST、ALT水平比较,差异无统计学意义(P>0.05)。两组术后5 d血清CRP水平明显高于术前(P<0.05),术后1 d血清CRP水平明显高于术前及术后5 d(P<0.05);且术后1 d、术后5 d时,LC组血清CRP水平明显低于OC组(P<0.05)。LC组术后1个月并发症总发生率明显低于OC组(P<0.05)。结论LC能引起急性胆囊炎患者一过性肝损伤,但在微创方面仍具有较大优势,能降低术后并发症发生风险,有利于患者术后康复。
【Objective】To investigate the effects of laparoscopic cholecystectomy(LC)on liver injury in patients with acute cholecystitis.【Methods】Forty-two cases of acute cholecystitis in LC group and open cholecystectomy(OC)group were retrospectively analyzed.The changes of aspartic acid aminotransferase(AST),alanine aminotransferase(ALT)and C-reactive protein(CRP)were recorded before surgery,1 day,and 5 days after surgery,and the complications 1 month after operation were compared.【Results】Compared with those before operation,there was no significant difference in the levels of serum AST and ALT 5 days after operation(P>0.05).However,serum AST and ALT 1 day after operation were significantly higher than before operation and 5 days after operation(P<0.05).There was no significant difference in serum AST and ALT levels between the two groups before and after the operation(P>0.05).The level of serum CRP 5 days after operation was significantly higher than that before operation(P<0.05),and serum CRP 1 day after operation was significantly higher than that before and 5 days after operation(P<0.05).One day and 5 days after operation,the serum CRP level of LC group was significantly lower than that of OC group(P<0.05).The total incidence of complications 1 month after operation was significantly lower in LC group than in OC group(P<0.05).【Conclusion】LC can cause transient liver damage in patients with acute cholecystitis,but it can also reduce surgical trauma and reduce postoperative complications,and is beneficial for postoperative rehabilitation.
作者
陈铁军
苑军正
CHEN Tiejun;YUAN Junzheng(Department of General Surgery,Traditional Chinese Medicine Hospital of Yancheng District in Luohe City,Luohe,Henan 462300,China;Department of General Surgery,the First Affiliated Hospital of Henan University of CM,Zhengzhou,Henan 450000,China)
出处
《中国医学工程》
2020年第2期27-29,共3页
China Medical Engineering
