摘要
目的对马来西亚产东革阿里(Eurycoma longifolia Jack)叶中的化学成分进行研究,为其资源开发与应用提供依据。方法综合应用大孔吸附树脂、正相硅胶、反相ODS柱和Sephadex LH-20等柱色谱以及高效液相色谱法对东革阿里叶的化学成分进行分离和纯化,并结合单体成分的理化性质与核磁共振波谱数据鉴定其结构。结果从东革阿里叶的体积分数70%乙醇提取物中分离出6个紫罗兰酮类和4个木脂素类成分,分别鉴定为icariside B5(1)、euodionoside F(2)、(6R,9R)-3-oxo-α-ionolβ-D-glucopyranoside(3)、roseosideⅡ(4)、(6S,9S)-roseoside(5)、glochidionionoside D(6)、threo-1,2-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanediol-4’-O-β-D-glucopyranoside(7)、(-)-secoisolariciresinol 4-O-β-D-glucopyranoside (8)、(7R,8S,7’R,8’S)-syringaresinol-4-O-β-D-glucopyranoside(9)和syringaresinol diglucoside(10)。结论从东革阿里叶中分离鉴定了6个紫罗兰酮类和4个木脂素类单体成分。化合物1~10均为首次从该属植物中分离得到。
In order to promote the development of Eurycoma longifolia Jack,the chemical constituents of its leaves have been studied. Six ionones and four lignans have been isolated by using multiple chromatographic methods including D101 resin,silica gel,Sephadex LH-20,ODS and HPLC,and their structures were identified as icariside B5(1),euodionoside F(2),( 6R,9R)-3-oxo-α-ionol β-D-glucopyranoside( 3),roseoside Ⅱ( 4),( 6 S,9 S)-roseoside(5),glochidionionoside D(6),threo-1,2-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanediol-4’-O-β-D-glucopyranoside(7),(-)-secoisolariciresinol 4-O-β-Dglucopyranoside(8),( 7R,8S,7’R,8’S)-syringaresinol-4-O-β-D-glucopyranoside(9),and syringaresinol diglucoside( 10),respectively,by combining the physicochemical properties with spectral data. All of them were firstly obtained from Eurycoma genus.
作者
王剑丽
李正
阮静雅
张颖
王涛
张祎
WANG Jian-li;LI Zheng;RUAN Jing-ya;ZHANG Ying;WANG Tao;ZHANG Yi(Tianjin University of Traditional Chinese Medicine,Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin,Tianjin 300193,China)
出处
《中国药物化学杂志》
CAS
CSCD
北大核心
2020年第2期101-106,123,共7页
Chinese Journal of Medicinal Chemistry
基金
国家自然科学基金面上项目(81673688)
十三五重大新药创制项目(2018ZX09711001-009-010).
关键词
东革阿里
化学成分
紫罗兰酮
木脂素
结构鉴定
Eurycoma longifolia Jack
chemical constituents
ionones
lignans
structure identification
作者简介
王剑丽(1992-),女(汉族),黑龙江鹤岗人,硕士研究生,主要从事中药化学研究,E-mail:wjl15802226160@126.com;通信作者:张祎(1974-),女(汉族),河北唐山人,教授,博士,博士生/硕士生导师,主要从事药效物质基础研究,Tel:(022)59596163,E-mail:zhwwxzh@263.net。
