摘要
目的研究宽筋藤(中华青牛胆Tinospora sinensis藤茎)的化学成分。方法利用硅胶、Sephadex LH-20等柱色谱和半制备HPLC等进行分离和纯化,根据波谱数据和理化性质对化合物的结构进行鉴定。结果从宽筋藤的正丁醇萃取部位中分离得到16个化合物,分别鉴定为紫丁香苷(1)、corchoionoside C(2)、3,4-二甲氧基苯基-β-D-吡喃葡萄糖苷(3)、肉桂醇-O-β-D-吡喃葡萄糖苷(4)、3,4,5-三甲氧基苯酚-β-D-吡喃葡萄糖苷(5)、benzyl-β-D-glucopyranoside(6)、丁香酸(7)、3,5-二甲氧基苯甲酸-4-O-β-D-葡萄糖苷(8)、1,4-dihydroxymethyl-2,5-dimethoxybenzene(9)、1-[2-(furan-2-yl)-2-oxoethyl]pyrrolidin-2-one(10)、cordysinin B(11)、lyciumide A(12)、酪氨酸(13)、环(亮氨酸-异亮氨酸)(14)、表丁香树脂醇(15)、(+)-syringaresinol-4′-O-β-D-glucopyranoside(16)。结论化合物2、9~14均为首次从青牛胆属植物中分离得到。
Objective To study the chemical constituents from n-butanol parts of Tinosporae Caulis. Methods The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 and semi-HPLC. The structures were identified by spectroscopic methods and physicochemical properties. Results Sixteen compounds were isolated and identified from the n-butanol parts of Tinosporae Caulis as syringin(1), corchoionoside C(2), 3,4-dimethoxyphenyl-β-D-glucopyranoside(3), cinnamol-O-β-D-glucopyranoside(4), 3,4,5-trimethoxylphenol-β-D-glucopyranoside(5), benzyl-β-D-glucopyranoside(6), syringic acid(7), 3,5-dimethoxybenzoic acid-4-O-β-D-glucoside(8), 1,4-dihydroxymethyl-2,5-dimethoxy benzene(9), 1-[2-(furan-2-yl)-2-oxoethyl] pyrrolidin-2-one(10), cordysinin B(11), lyciumide A(12), tyrosine(13), cyclo-(Leu-Ile)(14),(-)-episyringaresinol(15), and(+)-syringaresinol-4′-O-β-D-glucopyranoside(16). Conclusion Compounds 2 and 9—14 are isolated from Tinospora genus for the first time.
作者
詹煌
陈佳倩
朱梦贞
张火娥
万思媛
黄丽萍
黄慧莲
ZHAN Huang;CHEN Jia-qian;ZHU Meng-zhen;ZHANG Huo-e;WAN Si-yuan;HUANG Li-ping;HUANG Hui-lian(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;College of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第3期594-598,共5页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81660713)
江西省科技厅计划项目(20165BCB18006)
江西省科技厅计划项目(20172BCB22010).
作者简介
詹煌(1992—),在读硕士,从事中药化学研究。E-mail:916949635@qq.com;通信作者:黄慧莲(1973—),教授,从事中药与天然药物化学研究。E-mail:huilianh@163.com
