摘要
肺腺癌是最常见的恶性肿瘤之一,其发病率和死亡率逐年上升。肺腺癌在早期阶段没有特异性的临床症状,缺乏有效的检测,使得早期发现变得困难。大多数患者在检测时已经处于晚期,预后差。肺癌细胞源性的外泌体(Lung cancer cell-derived exosomes, LCCDEs)由于其生物学功能和携带供体细胞生物分子的天然能力在肺腺癌的早期诊断及治疗中具有非常重要的作用,因此提高对外泌体的认识及研究对目前肺腺癌的早期诊断、早期治疗及预后有着十分重要的作用。本文就肺癌细胞源性外泌体在肺腺癌中的发生、诊断及治疗等研究进展做一综述。
Lung adenocarcinoma is one of the most common malignant tumors, and its morbidity and mortality are increasing year by year. Lung adenocarcinoma has no specific clinical symptoms in its early stages, and the lack of effective detection makes early detection difficult. Most patients are already in an advanced stage at the time of detection and have a poor prognosis. Lung cancer cell-derived exosomes (LCCDEs) play an important role in the early diagnosis and treatment of lung adenocarcinoma due to their biological function and natural ability to carry donor cell biomolecules. Therefore, it is very important to improve the understanding and study of exosomes for the early diagnosis, treatment and prognosis of lung adenocarcinoma. This article reviews the progress in the development, diagnosis and treatment of lung cancer cell-derived exosomes in lung adenocarcinoma.
出处
《临床个性化医学》
2025年第3期313-320,共8页
Journal of Clinical Personalized Medicine
基金
陕西省西安市科技计划项目(编号:2024YXYJ0004)
陕西省西安市卫生健康委员会科研项目(编号:2025yb07)
陕西省重点项目–关键核心技术攻关(编号:2024SF2-GJHX-64)
陕西省西安市科技计划项目(编号:23YXYJ0061)。
