摘要
卵巢癌是女性三大恶性肿瘤之一,严重危害女性生命健康。卵巢癌发生发展过程中,众多信号通路发挥着至关重要的作用,其中NF-κB信号通路是主要调控通路之一。近年来,中医药抗肿瘤的优势逐渐显现,研究发现,人参皂苷Rg1、沙苑子苷A、黄芩苷和芍药内酯苷等多种中药单体可以通过调控NF-κB信号通路发挥抑制卵巢癌细胞增殖、迁移和侵袭,或诱导细胞凋亡。基于国内外研究现状,通过整理归纳中药单体通过调控NF-κB信号通路干预卵巢癌的研究进展,力求为中医药治疗卵巢癌提供参考,同时也为临床用药研发开拓思路。Ovarian cancer is one of the three major malignant tumours in women, which seriously endangers women’s life and health. During the development of ovarian cancer, many signalling pathways play a crucial role, among which NF-κB signalling pathway is one of the major regulatory pathways. In recent years, the anti-tumour advantages of traditional Chinese medicine have gradually emerged, and it has been found that a variety of traditional Chinese medicine monomers, such as ginsenoside Rg1, saxifrageoside A, baicalin and paeonolactone glycosides, can inhibit the proliferation, migration and invasion of ovarian cancer cells or induce apoptosis by regulating the NF-κB signalling pathway. Based on the current research situation at home and abroad, we are trying to provide reference for the treatment of ovarian cancer with traditional Chinese medicine and develop ideas for clinical drug development by summarising the research progress of the intervention of traditional Chinese medicine monomers in ovarian cancer through regulating the NF-κB signaling pathway.
出处
《临床个性化医学》
2024年第3期944-950,共7页
Journal of Clinical Personalized Medicine
