摘要
抗反转录病毒治疗(Antiretroviral therapy, ART)的问世使越来越多的艾滋病病毒感染者的寿命得以延长,并在一定程度上大大降低了艾滋病相关疾病的发病率与死亡率,但随着艾滋病患者年龄的增加,各种慢性合并症(血脂异常、糖尿病、心血管疾病等)发病率越来越高。传统的风险因素、ART的应用及HIV导致的长期慢性炎症与免疫激活,使艾滋病患者的血脂、血糖代谢受到严重影响,由此发生的各种慢性合并症逐渐成为艾滋病患者死亡的主要原因。所以人们迫切需要了解艾滋病患者的血糖、血脂代谢特点,早期进行干预,改善患者的生存及预后。现就国内外艾滋病患者血脂、血糖代谢的研究现状加以综述。
The advent of antiretroviral therapy (ART) prolongs the life of more and more HIV-infected people and greatly reduces the morbidity and mortality of AIDS-related diseases to a certain extent. How-ever, with the increase of age of AIDS patients, the incidence of various chronic complications (hy-pertension, diabetes, cardiovascular diseases, etc.) is increasing. Traditional risk factors, the appli-cation of ART and the long-term chronic inflammation and immune activation caused by HIV have seriously affected the metabolism of blood lipids and blood glucose in AIDS patients, and various chronic complications resulting from this have gradually become the main cause of death in AIDS patients. Therefore, it is urgent for people to understand the characteristics of glucose and lipid metabolism in AIDS patients, and to carry out early intervention to improve the survival and prog-nosis of patients. This paper reviews the research status of blood lipid and blood glucose metabo-lism in AIDS patients at home and abroad.
出处
《临床医学进展》
2022年第8期7307-7313,共7页
Advances in Clinical Medicine
