摘要
目的 观察IEP方案与EP方案治疗小细胞肺癌的疗效和安全性。方法 64例小细胞肺癌患者按随机数字表法分为IEP组和EP组 ,每组 3 2例。结果 64例患者均可评价疗效和毒副反应。IEP组总有效率、局限期和广泛期有效率分别为 84.4%( 2 7/ 3 2 )、10 0 .0 %( 15 / 15 )和 70 .6%( 12 / 17) ,EP组分别为75 .0 %( 2 4/ 3 2 )、85 .7%( 12 / 14 )和 66.7%( 12 / 18) ,两组间比较均无显著性差异 (P >0 .0 5 )。IEP组中位缓解期和 1年生存率分别为 6月和 62 .5 %,EP组分别为 5月和 5 6.2 %(P >0 .0 5 )。两组共同的毒性反应为骨髓抑制 ,IEP组Ⅲ～Ⅳ度白细胞下降、恶心、呕吐、脱发发生率均明显高于EP组 (P <0 .0 1)。结论 IEP和EP方案均为治疗小细胞肺癌的有效方案 ,毒性反应可耐受。两方案临床疗效相似 ,均可作为治疗小细胞肺癌的一线方案。
Objective To observe and compare the efficacy and safety of IEP and EP regimens for small cell lung cancer (SCLC). Methods Sixty four patients with SCLC pathologically proved were randomly divided into IEP group ( n =32) and EP group ( n =32). Results All the 64 patients were evaluable for response and toxicity. In IEP group, the total responsive rate, responsive rates of limited stage patients and extensive stage patients were 84.4%(27/32), 100.0%(15/15) and 70.6%(12/17) respectively; while in EP group, those were 75.0%(24/32), 85.7%(12/14) and 66.7% (12/18) respectively. The median duration of remission was 6 months and 1 year survival rate was 62.5% in IEP group, and 5 months and 56.2% in EP group. There was no significant difference in response rate, median duration of remission and 1 year survival between the two groups ( P >0.05). The main toxicity was myelosuppression. Incidences of leukopenia at grade Ⅲ Ⅳ, nausea, vomiting and alopecia were significantly higher in the IEP arm than those in the EP arm ( P < 0.01 ). Conclusion High response rates and tolerable toxicities are attainable for small cell lung cancer treated with IEP and EP. IEP regimen shows a similar response rate compared with EP regimen. They might be considered as relevant regimens in initial patients with small cell lung cancer.
出处
《中国肺癌杂志》
CAS
2004年第3期240-242,共3页
Chinese Journal of Lung Cancer
关键词
小细胞肺癌
异环磷酰胺
顺铂
足叶乙甙
化疗
Small cell lung cancer Ifosfamide Cisplatin Etoposide Chemotherapy
