摘要
[目的]研究复发性、难治性中高度恶性非霍奇金淋巴瘤的解救治疗。[方法]37例复发性、难治性中高度恶性非霍奇金淋巴瘤病人用IEP方案治疗 :异环磷酰胺 (IFO)2g静脉点滴 ,第1～4天 (同时使用美斯纳 ) ;足叶乙甙 (Vp_16)100mg,静脉点滴 ,第1～4天 ;顺铂30mg/m2,静脉点滴 ,第1～3天 ;21～28天为1周期 ,连用2周期评定疗效。[结果]总缓解率为81.1% (30/37) ,完全缓解率(CR)为35.1% (13/37) ,部分缓解率为45.9% (17/37)。主要不良反应为骨髓抑制和脱发。白细胞减少发生率为83.8% ,其中Ⅲ～Ⅳ度发生率占43.2%。血红蛋白及血小板减少发生率分别为37.8%和43.2%。脱发发生率为91.2%。其它不良反应少见。[结论]IEP方案可作为复发性。
To study the salvage treatment of relapsed or refractory intermediate-high aggressive non-Hodgkin lymphoma (NHL). Thirty-seven cases with relapsed or refractory intermediate_high aggressive NHL received chemotherapy of IEP regimen:ifosfamide(IFO)2g iv,gtt d1～4;etoposide(Vp_16)100mg iv,gtt d1～4, cisplatin(DDP)30mg/m2 iv,gtt d1～3,every 21～28 days. Assessment was given after 2 cycles.The overall response rate was 81.1%(30/37) and complete response rate was 35.1%(13/37),the partial response rate was 45.9%(17/37).The main toxicity was myelosuppression and alopecia. Leukopenia was observed in 83.8% of the patients, and grade Ⅲ～Ⅳ in 43.2%. Anenia and throbopenia was observed in 37.8% and 43.2% of the patients respectively, alopecia in 91.2%. Other side effects were uncommon.[Conclusions]IEP regimen is a salvage treatment for relapsed or refractory intermediate-high aggressive NHL.
出处
《肿瘤学杂志》
CAS
2002年第3期155-156,共2页
Journal of Chinese Oncology
