摘要
作者用卡铂和足叶乙甙方案（ＣＥ方案）治疗１２３例肺癌，并比较ＣＥ方案对小细胞肺癌和非小细胞肺癌的临床应用价值。结果表明，小细胞肺癌的疗效较好，总有效率为７２．４％（４２／５８），初治者总有效率为８１．６％（３１／３８），复治者总有效率为３０．０％（６／２０）；非小细胞肺癌的疗效较差，总有效率为１８．５％（１２／６５），初治者总有效率为２２．９％（８／３５），复治者总有效率为１３．３％（４／３０）。两类肺癌均为复治者疗效差，这可能与耐药等因素有关。ＣＥ方案主要表现在血液毒性，但不严重，其它副作用有消化道毒性、脱发及轻度的肝肾功能影响。在化疗中，对３５例患者外周血Ｔ细胞亚群进行检测，结果表明，ＣＥ方案对细胞免疫功能有一定影响，但这种影响可以在短期内很快恢复。因此，ＣＥ方案可以作为小细胞肺癌化疗的最佳选择方案之一，对非小细胞肺癌的疗效尚不满意。
Abstract The clinical effect of Carboplatin and Etoposide (CE regimen )on 58 cases of
small cell lung cance (SCLC)and 65 cases of non small cell lung cancer (NSCLC) was
observed, and its influcence on immunity was investigated simultaneously .The result showed
that the overall response rate of SCLC group was 72.4%(42/58). Among them,the response rate
of primary treatment was81.0%(31/38),and that of secpmdaru treatment was 30.0% In NSCLC
group,the response rate of primary treatment was 30.0%(6/20). In NSCLS group,the rate of
primary treatment was 22.9%(8/35),and that of secondary treatment was 13.3%(4/30).From the
result it was found that the response rate of primary treament was higher than that of
secondary treatment , and that the main side-effect of CE regimen was mild leukopenia,and the
other side effects included gastrointhestinal symptoms,alopecia and mild hepatic function
changes .The influcence of CE regimen on immunity was temporary, and will soon
recover.Repeating the regimen is reasonable.So we think that CE regimen is one of the best
regimens for SCLC patients.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第5期384-386,共3页
Chinese Journal of Oncology
