摘要
目的探讨丹酚酸B(SalvianolicacidB,SalB)治疗大鼠心肌梗死(myocardialinfarction,MI)以后的病理形态学变化。方法通过结扎冠状动脉左前降支制作大鼠心肌梗死模型,测定各组心肌梗死面积占总面积的百分比,并且对心肌梗死部位成纤维细胞和毛细血管进行计数,观察SalB对MI的干预作用。结果SalB可以减少心肌梗死面积,促进毛细血管的生长,加速梗死灶的修复。结论SalB可以减轻MI的面积,是中药丹参起效的重要物质基础之一,具有良好的开发及应用前景。
s: To explore the changes of pathomorphology in myocardial infarction(MI) rats after treatment with Salvianolic acid B(Sai B). MI rats model was made by ligation of left anterior descending branch of coronary artery. Assay the percentage of myocardial infarction area in total areas of each group, counting the fibroblast and blood capillary of myocardial infarction region, and observe the intervention action of Salvianolic acid B on myocardial infarction. Sai B can decrease the myocardial infarction areas, promote the growth of blood capillary, and accelerate the plerosis of infarction focus. [Conclusion] Sai B can decrease the myocardial infarction areas and is one of the important material basal in Danshen and have satisfactory development and application prospect.
出处
《天津中医学院学报》
2004年第1期12-14,共3页
Journal of Tianjin College of Traditional Chinese Medicine
基金
天津市科委资助课题(023611611)
