摘要
壳聚糖的N 乙酰基葡萄糖胺组成成分为糖胺聚的结构特征 ,而明胶则为胶原的部分变性衍生物 ,由其开发的生物材料呈现和前体相当的生物活性。本文综述了壳聚糖 明胶基生物材料的最近进展 ,包括用壳聚糖 明胶网络基生物材料制备膜材料、支架 ,且作为表面修饰剂用于组织工程。N 烷基化壳聚糖用作DNA释放的非病毒载体。这些生物材料在皮肤、软骨、骨组织工程和基因治疗方面呈现良好的应用前景。
Chitosan in which the N-acetylglucosamine moiety is a structural feature found in glucosaminoglycans and gelatin is the partially denatured derivative of collagen. They exhibit related bioactivities as their precursor. The recent achievements on the chitosan-gelatin network based biomaterials are reviewed is this paper covers preparations of membrane, scaffold, surfaces modifier in tissue engineering as well as the utilization of N-alkylated chitosan as non-viral vector for DNA delivery. These biomaterials have promising perspectives in skin, cartilage, bone tissue engineering and gene therapy.
出处
《应用化学》
CAS
CSCD
北大核心
2004年第3期217-222,共6页
Chinese Journal of Applied Chemistry
基金
国家重点基础规划项目 (G19990 5 3 0 5 )
国家自然科学基金 (5 9973 0 14
5 983 0 0 2
5 9883 0 0 2
5 0 2 3 3 0 2 0
5 0 2 0 3 0 0 7)
教育部南开大学天津大学合作研究项目
关键词
壳聚糖
明胶
表面修饰剂
生物材料
组织工程
综述
chitosan,gelatin,surface modification,biomaterial,tissue engineering,review
