摘要
目的 :研究左西孟旦、硝普钠与多巴酚丁胺治疗急性心力衰竭的临床疗效。方法 :选取我院收治的急性心力衰竭患者120例,按随机数字表法分为A组、B组和C组,各40例。A组予以左西孟旦[0.5μg/(kg·min)]治疗,B组予以硝普钠[0.5μg/(kg·min)]治疗,C组予以多巴酚丁胺[2.5μg/(kg·min)]治疗,三组均连续治疗14 d。比较三组临床疗效,治疗前后血清因子及心功能。结果 :治疗后,A组血清因子肌钙蛋白(hs-c Tn T)、超敏C反应蛋白(hs-CRP)、B型脑钠肽(BNP)低于B组和C组,差异有统计学意义(P <0.05);治疗后A组左心室收缩末期内径(LVESd)、左心室射血分数(LVEF)优于B组和C组,差异有统计学意义(P <0.05);A组治疗总有效率高于B组和C组,差异有统计学意义(P <0.05)。结论 :与硝普钠、多巴酚丁胺比较,左西孟旦治疗急性心力衰竭的疗效更显著,可调节血清因子水平,促进心功能恢复。
Objective:To study the clinical efficacy of levosimendan,sodium nitroprusside and dobutamine in the treatment of acute heart failure.Methods:120 patients with acute heart failure admitted to our hospital were randomly divided into group A(n=40),group B(n=40)and group C(n=40).The patients in the group A were treated with levosimendan(0.5μg/(kg·min))The patients in the group B was treated with sodium nitroprusside(0.5μg/(kg·min))The patients in the group C was treated with dobutamine(2.5μg/(kg·min))All patients in the three groups were treated for 14 days.The clinical efficacy,serum factors and cardiac functions before and after treatment were compared between the three groups.Results:After treatment,the levels of serum factor troponin(hs-cTnT),high-sensitivity C-reactive protein(hs-CRP)and B-type brain natriuretic peptide(BNP)in the groups A were lower than those in the group B and the group C,and the differences were statistically significant(P<0.05).After treatment,the left ventricular end systolic diameter(LVESd)and left ventricular ejection fraction(LVEF)in the group A were better than those in the group B and the group C,and the differences were statistically significant(P<0.05).The total effective rate in the group A was higher than that in the group B and the group C,and the differences were statistically significant(P<0.05).Conclusion:Compared with sodium nitroprusside and dobutamine,levosimendan is more effective in the treatment of acute heart failure,which can regulate serum factor levels and promote cardiac function recovery.
作者
刘芳芳
Liu Fang-fang(Department of Internal Medicine,People’s Hospital of Zhongzhan District,Jiaozuo Henan 454191,China)
出处
《中国合理用药探索》
CAS
2019年第8期19122-19124,19127,共4页
Chinese Journal of Rational Drug Use
关键词
左西孟旦
硝普钠
多巴酚丁胺
急性心力衰竭
Levosimendan
Sodium Nitroprusside
Dobutamine
Acute Heart Failure
作者简介
刘芳芳,女,主治医师。研究方向:心内科。E-mail:aopanhao538952@163.com
