摘要
葡萄膜炎是由自身免疫系统紊乱导致的一种较常见的炎症性致盲性眼部疾病。目前,国内外学者的研究普遍认为,葡萄膜炎主要是由CD4+T细胞介导产生。CD4+T细胞可分为辅助性T细胞1(Th1)、辅助性T细胞2(Th2)、辅助性T细胞17(Th17)及调节性T细胞(Treg)四个亚群。既往研究主要集中于Th1、Th2及Th17细胞亚群。近年来,随着相关研究的不断深入,国内外学者发现,Treg细胞是负向调控葡萄膜炎的主要因素。Treg细胞能够抑制自身反应性T细胞的免疫反应、抑制传统T细胞的活化及促进某些抑制性细胞因子的分泌,从而在控制机体自身免疫性疾病的发生中发挥着重要作用。有学者研究发现,Treg细胞对维持机体的正常免疫耐受性具有十分重要的作用,它的数量及功能变化与许多免疫相关疾病的发生和发展有关。本文中笔者就Treg细胞与自身免疫性葡萄膜炎(EAU)的相关性研究进展进行综述。
Uveitis is a more common inflammatory blind eye disease caused by autoimmune disorders. At present,scholars at home and abroad have found that uveitis is mainly mediated by CD4 + T cells. CD4 + T cells were mainly divided into four subsets,including helper T cells 1( Th1),helper T2 cells( Th2),helper T cells 17( Th17) and regulatory T cells( Treg). Previous studies were mainly focused on Th1,Th2 and Th17 cell subsets. In recent years,with the development of related research,scholars at home and abroad have found that Treg cells are the main factors in the negative regulation of uveitis. Treg cells can inhibit the immune response of self reactive T cells,inhibit the activation of traditional T cells and promote the secretion of some inhibitory cytokines, which play an important role in maintaining the occurrence of autoimmune diseases. Some scholars have found that Treg cells play a very important role in maintaining normal immune tolerance of the body. Its quantity and function changes are related to the development of many immune related diseases. In this paper,the research progress on the correlation between Treg cells and autoimmune uveitis( EAU) is reviewed.
出处
《中华眼科医学杂志（电子版）》
2018年第2期76-81,共6页
Chinese Journal of Ophthalmologic Medicine(Electronic Edition)
基金
国家自然科学基金(81273808)
湖南省中医药管理局项目(2209-38-64)
