摘要
目的评价注射用丹参多酚酸治疗脑梗死急性期患者的疗效及对超敏C反应蛋白(hs-CRP)和血液流变的影响。方法将80例脑梗死急性期患者依据随机数字表法分为观察组与对照组,每组40例。对照组采用常规西药治疗,观察组在对照组治疗基础上加用注射用丹参多酚酸0.13 g用0.9%氯化钠注射液稀释,静脉滴注1次/d。两组疗程均为14 d。比较两组治疗后疗效变化,治疗前后NIHSS评分、细胞炎症因子和血流变学水平的变化,并记录药物不良反应。结果治疗后,观察组总有效率95.0%,高于对照组的77.5%,两组比较差异有统计学意义(P<0.05);两组NIHSS评分均较治疗前下降,同组治疗前后比较差异有统计学意义(P<0.05);且观察组下降幅度高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者hs-CRP水平,血浆黏度、血沉、全血黏度高切、全血黏度低切水平相似,差异无统计学意义;治疗后,两组患者血清hs-CRP水平、血浆黏度、血沉、全血黏度高切、全血黏度低切水平均降低,,同组治疗前后比较差异有统计学意义(P<0.05);但观察组患者的降低幅度明显于对照组,差异比较有统计学意义(P<0.05)。治疗过程中,两组患者无明显的药物不良反应。结论注射用丹参多酚酸治疗脑梗死急性期患者疗效明确,可以降低hs-CRP水平和改善血液流变学,且比较安全。
Objective To investigate the effect of Salvianolic Acids for Injection(SAFI) in the treatment of patients with acute cerebral infarction and its effect on hs-CRP and hemorheology. Methods A total of 80 patients with acute cerebral infarction were randomly divided into treatment group( n = 40)and control group( n = 40). The patients in the control group were treated with conventional western medicine, and the patients in the treatment group received SAFI 0.13 g dissolved in 250 mL of 0.9% sodium chloride injection based on the treatment of control group, intravenous drip once a day. The course of treatment was 2 weeks in two groups. The therapeutic effects of two groups were compared. The changes of NIHSS score, cell cytokines and hemorheology levels before and after treatment and adverse reactions were also observed and recorded. Results After the treatment, the total effective rate of the treatment group(95.0%) was significantly higher than that of control group’s(77.5%)(P < 0.05). The NIHSS scores of the two groups were lower than those before treatment, and the NIHSS score of the treatment group was lower than the control group’s(P < 0.05). the serum hs-CRP level, plasma viscosity, ESR, high shear rate and low shear rate of whole blood viscosity in the two groups were all decreased, but the decrease of the observation group was significantly higher than that of the control group(P <0.05). During the treatment, there were no obvious adverse drug reactions in the two groups. Conclusion The curative effect of Salvianolic Acids for Injection in the treatment of acute cerebral infarction is confirmed, it can reduce the level of hs-CRP andimprove hemorheology, and it is relatively safe.
作者
刘雪洁
谢道俊
杨波
周磊
LIU Xuejie;XIE Daojun;YANG Bo;ZHOU Lei(Anhui University of Traditional Chinese Medicine,Hefei 230038,China;First Affiliated Hospital,Anhui University of Traditional Chinese Medicine,Hefei 230031,China)
出处
《药物评价研究》
CAS
2019年第2期296-300,共5页
Drug Evaluation Research
作者简介
第一作者:刘雪洁(1993—),女,硕士研究生,研究方向为神经内科疾病的诊治。Tel:13075576878 E-mail:972632991@qq.com;通信作者:谢道俊,男,主任医师,博士,硕士研究生导师,研究方向为神经内科疾病的诊治。E-mail:daojunxie81@163.com
