摘要
目的观察注射用丹参多酚酸治疗急性脑梗死的临床疗效。方法选取2017年6月—2018年6月安阳市第六人民医院治疗的急性脑梗死患者200例作为研究对象,将患者分为对照组和观察组,每组各100例。对照组给予抗血小板聚集、清除及抗自由基等治疗脑梗死的常规药物治疗,观察组在对照组治疗的基础上静脉滴入注射用丹参多酚酸,130 mg稀释于0.9%氯化钠溶液250 mL,1次/d。两组均治疗2周。比较两组患者治疗前后的美国国立卫生研究院卒中量表(NIHSS)和日常生活活动能力(ADL)评分,并观察两组患者的临床疗效。结果治疗后,两组NIHSS评分明显下降,ADL评分明显提升,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,观察组NIHSS评分明显低于对照组,ADL评分明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,观察组总有效率为95%,明显高于对照组的71%(P<0.05)。结论注射用丹参多酚酸应用于急性脑梗死患者的治疗疗效确定,可在很大程度上改善患者肢体运动功能和神经功能,提高日常生活质量,值得临床广泛推广使用。
Objective To observe the clinical effect of Salvianolic Acids for injection on acute cerebral infarction. Methods Patients(200 cases) with acute cerebral infarction in Anyang People’s Hospital NO.6 from June 2017 to June 2018 were randomly divided into control and observation group, and each group had 100 cases. Patients in the control group was treated with conventional drugs for treating cerebral infarction, such as anti-platelet aggregation, scavenging and anti-free radical. Patients in the observation group were iv administered with Salvianolic Acids for injection on the basis of control group, 130 mg diluted in 0.9% sodium chloride solution 250 mL, once daily. Patients were treated for 2 weeks. The NIHSS and ADL scores before and after treatment were compared between two groups, and the clinical efficacy of the two groups was observed. Results After treatment, the NIHSS score in two groups were significantly decreased, but the ADL score were increased, the difference between two groups before and after treatment was statistically significant(P < 0.05). After treatment, NIHSS score in the observation group was significantly lower than that in the control group, and the ADL score was significantly higher than that in the control group, the difference between two groups was statistically significant(P < 0.05). After treatment, the total effective rate of observation group was 95%, which was significantly higher than 71% in the control group(P < 0.05). Conclusion The therapeutic effect of Salvianolic Acids for injection in treatment of acute cerebral infarction can be determined, which can greatly improve the limb motor function and nerve function of patients, improve the quality of daily life, and is worthy of widespread clinical use.
作者
任会菊
乔洪潮
郑东焕
高园园
王常有
黄利红
REN Huiju;QIAO Hongchao;ZHENG Donghuan;GAO Yuanyuan;WANG Changyou;HUANG Lihong(Department of Neurology,Anyang People's Hospital NO.6,Anyang 455000,China)
出处
《药物评价研究》
CAS
2020年第3期502-505,共4页
Drug Evaluation Research
作者简介
第一作者:任会菊(1973-),女,本科,副主任医师,研究方向为急性缺血性脑血管病的临床治疗,E-mail:1290529879@qq.com
