摘要
芹菜素是一种天然的黄酮类化合物,广泛存在于多种水果、蔬菜和草药中,具有抗肿瘤、抗氧化、抗炎等多种生物学作用。芹菜素在抗肿瘤方面效果显著,可抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤侵袭和转移、干扰肿瘤细胞的信号转导、逆转细胞耐药性,提高化疗药物敏感性和抗氧化作用等。本文综述了芹菜素主要的生物学作用及抗肿瘤作用机制,并展望了芹菜素的应用开发前景。
Apigenin is a natural flavonoid compound that is widely found in various fruits, vegetables and herbs, and has various biological effects such as anti-tumor, anti-oxidation and anti-inflammatory. Apigenin has significant anti-tumor effects, which can inhibit tumor cell proliferation, induce apoptosis of tumor cells, inhibit tumor invasion and metastasis, interfere with signal transduction of tumor cells, reverse drug resistance of cells, increase the sensitivity of chemotherapeutic drugs and anti-oxidation, etc. This review summarizes the main biological effects of apigenin and its anti-tumor mechanisms, and looks forward to the prospects of application and development of apigenin.
作者
陈亭亭
杨培伟
张树辉
CHEN Tingting;YANG Peiwei;ZHANG Shuhui(Yueyang Clinical Medical College,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2019年第4期507-510,共4页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81172311)
上海中医药大学中西医结合I类高原学科(30304114325)
关键词
芹菜素
肿瘤
抗肿瘤机制
研究进展
apigenin
tumor
anti-tumor mechanism
progress in research
作者简介
陈亭亭,女,博士生Tel:13248182050.E-mail:1140526045@qq.com;通信作者:张树辉,男,博士,主任医师Tel:18930568163.E-mail:shzhang@126.com.
