摘要
经典的Wnt/β-catenin信号通路参与调控机体的多种生物学功能,包括干细胞自我更新,细胞的增殖、分化、凋亡以及胚胎早期发育和组织再生等,与癌症发生发展紧密相关。此外,该信号通路在胸腺T细胞的发育和分化过程中发挥重要作用,影响抗肿瘤免疫效应的多个环节。异常激活的Wnt/β-catenin信号通路可诱导恶性肿瘤的形成并介导肿瘤免疫逃逸。详细阐述了Wnt/β-catenin信号通路与癌症发生发展及抗肿瘤免疫治疗的相关性,讨论了靶向Wnt/β-catenin信号通路药物的临床研究进展及其应用于疾病治疗领域所要面临的挑战和局限性。
The classic Wnt/β-catenin signaling pathway is involved in regulating various biological functions including stem cell self-renewal,cell proliferation,differentiation,apoptosis,early embryonic development and tissue regeneration,and it is closely related to the occurrence and development of cancer.In addition,this signaling pathway plays an important role in the development and differentiation of thymic T cells,and affects many aspects of the anti-tumor immune effect.Abnormally activated Wnt/β-catenin signaling pathway can induce the formation of malignant tumors and mediate tumor immune escape.This review elaborated on the correlation of Wnt/β-catenin signaling pathway with cancer occurrence and development as well as anti-tumor immunotherapy,and discussed the research progress of drugs targeting Wnt/β-catenin signaling pathway,and the challenges and limitations of its clinical application.
作者
张慧
陈华宁
库德莱迪·库尔班
王松娜
刘嘉扬
赵缜
叶丽
ZHANG Hui;CHEN Hua-ning;KUDELAIDI Kuerban;WANG Song-na;LIU Jia-yang;ZHAO Zhen;YE Li(Biological Medicines and Shanghai Engineering Research Center of Immunotherapeutics,School of Pharmacy,Fudan University,Shanghai 201203,China;Clinical Laboratory,Minhang Hospital,Fudan University,Shanghai 201199,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2022年第1期104-111,共8页
China Biotechnology
基金
上海市科委生物医药科技支撑专项(20S11901600、18431902800)资助项目
作者简介
通讯作者:叶丽,电子信箱:yelil@fudan.edu.cn;通讯作者:赵缜,电子信箱:fdmh_zz@fudan.edu.cn
