摘要
Nanomaterials have been applied as antibacterial agents by virtue of their unique functioning mechanism different from that of conventional antibiotics.Cerium oxide nanoparticles(CeO2 NPs)are important antibacterial agents due to their relatively low toxicity to normal cells and their distinct antibacterial mechanism based on the reversible conversion between two valence states of Ce(III)/Ce(IV).Some studies have been conducted to explore their antibacterial activities;however,systematic research reviews on the related mechanisms and influencing factors are still quite rare.In this review,we discuss the plausible mechanisms of the antibacterial activity of CeO2 NPs,analyze different influencing factors,and summarize various research reports on antibacterial effects on E.coli and S.aureus.We also propose the potential applications and prospects,and hope to provide an in-depth understanding on the antibacterial mechanism and a better guidance to the design and applications of this promising antibacterial material in the future.
纳米材料因其特殊的抗菌机理,在抗菌领域得到了广泛应用.氧化铈纳米粒子是重要的抗菌材料之一,具有对正常细胞毒性低,且抗菌机理基于可逆价态转化的优势.目前已有许多关于氧化铈纳米粒子抗菌活性的研究报道,但系统性探究其抗菌机理的文章则极为少见.本文首先系统性地探究了氧化铈纳米粒子可能的抗菌机理,即静电相互作用在抗菌过程中发挥重要作用,此外抗菌过程还伴随活性氧物种的产生和纳米粒子对细菌的机械损伤.其次,本文分析了氧化铈纳米粒子抗菌效果的影响因素,并总结了不同研究中氧化铈纳米粒子对大肠杆菌和金黄葡萄球菌的抗菌效果.最后提出了氧化铈纳米粒子可能的应用前景.本文将有利于对氧化铈纳米粒子抗菌机理的深入理解,并为该类材料在未来的设计和应用提供借鉴.
作者
Mengzhen Zhang
Chao Zhang
Xinyun Zhai
Feng Luo
Yaping Du
Chunhua Yan
张萌真;张超;翟欣昀;罗锋;杜亚平;严纯华(Tianjin Key Lab for Rare Earth Materials and Applications,Center for Rare Earth and Inorganic Functional Materials,School of Materials Science and Engineering&National Institute for Advanced Materials,Nankai University,Tianjin 300350,China;IMDEA Nanoscience,Faraday 9,Ciudad Universitaria de Cantoblanco,Madrid 28049,Spain;Beijing National Laboratory for Molecular Sciences,State Key Laboratory of Rare Earth Materials Chemistry and Applications,PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China)
基金
support from the National Funds for Excellent Young Scientists of China (21522106)
the National Key R&D Program of China (2017YFA0208000)
the 111 Project (B18030) from China
作者简介
Corresponding author:Yaping Du,(emails:ypdu@nankai.edu.cn,is a full professor at the School of Material Science and Engineering,Nankai University.He is the director of Tianjin Key Lab for Rare Earth Materials and Applications and Deputy Director of the Centre for Rare Earth and Inorganic Functional Materials.His research interests focus on rare-earth functional materials.He has more than 90 publications in peer-reviewed scientific journals and was a winner of the National Science Fund for Excellent Young Scholars in 2015.He received his BSc degree from Lanzhou University in 2004 and PhD degree from Peking University in 2009;Corresponding author:Xinyun Zhai,xyzhai@nankai.edu.cn,is a lecturer at the School of Material Science and Engineering,Nankai University.She received her BSc degree and MSc degree from Tianjin University in 2010 and 2013,respectively and PhD degree from The University of Hong Kong in 2017.Her research interests focus on rare-earth based biomedical materials and rare-earth based functional materials;Mengzhen Zhang is a PhD student at the School of Chemistry,Nankai University.Her research interest focuses on the rare earth based functional materials;Chunhua Yan is the President of Lanzhou University and the Director of the State Key Laboratory of Rare Earth Materials Chemistry and Applications at Peking University,and the Center for Rare Earth and Inorganic Functional Materials at Nankai University.He received his BSc,MSc,and PhD degrees from Peking University.
