摘要
目的:探讨补肾安神法对轻度抑郁焦虑伴失眠患者血清5-羟色胺(5-HT)水平及抑郁自评量表(SDS)、焦虑自评量表(SAS)积分影响。方法:选取74例抑郁焦虑伴失眠患者作为观察对象,随机分为对照组和补肾安神组,每组37例。均予安慰、鼓励、帮助、同情、换位思考等心理支持治疗,对照组予米氮平片15 mg/次,每晚睡前口服,补肾安神组在此基础上予乌灵胶囊3粒/次,3次/d口服。检测血清单胺类神经递质变化,采用抑郁自评量表(SDS)、焦虑自评量表(SAS)评估抑郁、焦虑情绪,采用匹兹堡睡眠质量指数(PSQI)评估睡眠质量,比较临床效果。结果:与治疗相比,两组治疗4、8周后血清多巴胺(DA)、去甲肾上腺素(NE)、5-羟色胺(5-HT)升高(P<0.05),SDS、SAS评分降低(P<0.05),入睡时间、睡眠时间、睡眠效率、睡眠障碍、睡眠质量、日间功能及PSQI总分降低(P<0.05);与同时间对照组相比,补肾安神组治疗4、8周后血清DA、NE、5-HT较高(P<0.05),SDS、SAS评分较低(P<0.05),睡眠效率、睡眠障碍、睡眠质量、日间功能及PSQI总分较低(P<0.05),总有效率较高(P<0.05)。结论:补肾安神法治疗轻度抑郁焦虑伴失眠效果显著,可降低SDS、SAS积分,可能与上调5-HT表达有关。
Objective:To explore the effect of kidney-nourishing and mind-tranquilizing method in the treatment of mild depression and anxiety and insomnia on serum 5-HT level,SDS and SAS scores.Methods:Seventy-four patients with depression and anxiety and insomnia were selected as the subjects,and were randomly divided into the control group and the kidney-nourishing and mind-tranquilizing group,37 cases in each.All patients received psychological support therapy such as comfort,encouragement,help,sympathy and empathy.The control group received Mirtazapine Tablets 15 mg before going to bed.The kidney-nourishing and mind-tranquilizing group additionally received Wuling Capsule 3 times/day,and levels of monoamine neurotransmitter,scores of self rating Depression Scale(SDS),self rating Anxiety Scale(SAS) assessment of depression and anxiety were recorded,and the clinical effect was compared.Results:Compared with those before treatment,levels of serum dopamine(DA),norepinephrine(NE),5-hydroxytryptamine(5-HT) 4 and 8 weeks after treatment in two groups increased(P<0.05) and scores of SDS and SAS decreased(P<0.05).The sleep time,sleep time,sleep efficiency,sleep disorders,sleep quality and daytime function and the total score of PSQI decreased(P<0.05).Compared with the control group,levels of serum dopamine(DA),norepinephrine(NE),5-hydroxytryptamine(5-HT) 4 and 8 weeks after treatment in the kidney-nourishing and mind-tranquilizing group were higher(P<0.05) and scores of SDS and SAS were lower(P<0.05).The sleep time,sleep time,sleep efficiency,sleep disorders,sleep quality and daytime function and the total score of PSQI were lower,and the total efficiency was higher(P<0.05).Conclusion:Kidney-nourishing and mind-tranquilizing method on mild depression and anxiety with insomnia is significant,and can reduce the scores of SDS and SAS,which may be related to the up-regulation of 5-HT expression.
作者
刘卫花
黄宏敏
赵光峰
LIU Weihua;HUANG Hongmin;ZHAO Guangfen(Hainan Provinical Hosptial of TCM,Haikou 570203,Hainan,China)
出处
《辽宁中医杂志》
CAS
2019年第2期303-306,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
抑郁焦虑
失眠
补肾安神法
5-HT
depression and anxiety
insomnia
kidney-nourishing and mind-tranquilizing
5-HT
作者简介
刘卫花(1984-),女,山东人,主治医师,学士,研究方向:神经内科。
