摘要
目的分析脑卒中后抑郁(PSD)与血浆致动脉硬化指数(AIP)及残余胆固醇(RC)的关系。方法选取华北理工大学附属医院神经内科2020年11月至2021年12月收治的219例缺血性脑卒中患者,汉密尔顿抑郁量表(HAMD-24)于发病后第14天完成评估,将患者分为PSD组及脑卒中后非抑郁(NPSD)组。分别测定两组患者血脂水平并计算AIP、RC,评估神经功能情况:美国国立卫生研究院卒中量表(NIHSS)及独立活动能力:日常生活活动能力量表(ADL)。结果219例患者中,PSD患者82例(37.4%),PSD组与NPSD组NIHSS评分、ADL评分、合并糖尿病、高血压的比例,差异均具有统计学意义(t=-2.593、3.189、11.940、6.742,P<0.05);PSD组比NPSD组AIP、RC水平高(t=-8.868、-5.672,P<0.01),且HAMD-24项量表得分与AIP、RC水平呈正相关(r=0.502、0.349,P<0.05)。AIP、RC水平、ADL得分、NIHSS得分对PSD有正向预测力(P<0.05)。结论AIP、RC水平变化可能是PSD的预测因素,AIP、RC水平增高,可能发生PSD的风险增大。
Objective To analyze the relationship between post-stroke depression(PSD)and plasma atherogenic index(AIP)and residual cholesterol(RC).Methods Two hundred and nineteen ischemic stroke patients admitted to the department of neurology of the Affiliated Hospital of North China University of Science and Technology from November 2020 to December 2021 were selected,and the Hamilton Depression Scale(HAMD-24)was completed on the 14th day after the onset of stroke to assess the patients,and the patients were divided into PSD group and non-PSD(NPSD)group.Lipid levels were measured and AIP and RC were calculated,neurological function[National Institutes of Health Stroke Scale(NIHSS)]and independent mobility ability[Activities of Daily Living Scale(ADL)]were assessed in the two groups,respectively.Results Among 219 patients,82 had PSD(37.4%).The differences of NIHSS score,ADL score,the proportions of combined diabetes and hypertension were statistically significant between the PSD group and the NPSD group(t=-2.593,3.189,11.940,6.742;P<0.05).Compared with the NPSD group,the AIP,RC levels in PSD group were high(t=-8.868,-5.672;P<0.01),and HAMD scores was positively correlated with AIP and RC levels(r=0.502,0.349;P<0.05).AIP,RC levels,ADL scores,NIHSS scores had positive predictive power for PSD(P<0.05).Conclusion AIP and RC levels are predictors of PSD,and the higher the AIP and RC levels,the greater the risk of PSD.
作者
苑杰
郭子琦
牛晓琳
李秋艳
曹文彬
项颖
王静
Yuan Jie;Guo Ziqi;Niu Xiaolin;Li Qiuyan;Cao Wenbin;Xiang Ying;Wang Jing(Institute of Mental Health,North China University of Science and Technology,Tangshan 063000,China;North China University of Science and Technology,Tangshan 063000,China;Tangshan Union Medical College Hospital,Tangshan 063000,China;Yu Tian County Chinese Medicine Hospital,Tangshan 063000,China;Tangshan Vocational and Technical College,Tangshan 063000,China)
出处
《心脑血管病防治》
2022年第6期5-8,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
基金
河北省2020年度医学科学研究课题(20201216)
作者简介
通信作者:王静,Email:mdwangjing@126.com
