摘要
目的探讨右美托咪定应用于肺癌根治手术患者对患者的认知功能、炎症反应及氧化应激水平的影响。方法选取2014年1月至2016年3月在我院拟行肺癌根治手术的患者120例,采用SPSS生成随机数字表分为A组(切皮时给予0.8μg/kg的右美托咪定输注,之后以0.3μg/kg维持至术毕)、B组(切皮时给予0.8μg/kg的右美托咪定输注,之后以0.5μg/kg维持至术毕)、C组(仅给予等量生理盐水)各40例,三组患者的麻醉诱导及维持药物均一致。结果术后72h,B组的MMSE评分高于A组和C组(P<0.05),A组的MMSE评分高于C组(P<0.05);术后72h,B组的POCD发生率低于A组和C组(P<0.05),A组的POCD发生率低于C组(P<0.05);术前,A、B、C三组患者的血清TNF-α、IL-6、SOD、MDA的水平差异无统计学意义(P>0.05);术后24h、术后72h、术后1周,B组的TNF-α、IL-6、MDA的水平低于A组和C组(P<0.05),SOD水平高于A组和C组(P<0.05);A组的TNF-α、IL-6、MDA的水平低于C组(P<0.05),A组的SOD水平高于C组(P<0.05)。结论 0.8μg/kg的右美托咪定输注及0.5μg/kg维持剂量有利于减轻肺癌根治手术患者的氧化应激、炎症反应、降低患者术后POCD发生率。
Objective To investigate the effect of dexmedetomidine on MMSE score,inflammatory reaction and oxidative stress in patients with lung cancer. Methods From January 2014 to March 2016 in our hospital,120 patients underwent radical surgery of lung cancer,produced by SPSS were randomly divided into the A group( 0. 8 g/kg skin incision given dexmedetomidine infusion,followed by 0. 3 g/kg maintained until the end of operation),and the B group( given 0. 8 g/kg skin incision the dexmedetomidine infusion,followed by 0. 5 g/kg until the surgery)and the group C( given only saline),40 cases in each group. Their induction and maintenance of anesthesia drugs were consistent among the three groups. Results After 72 h,MMSE was higher in the B group than in the A group and the C group( P < 0. 05),and the A group was higher than the C group( P < 0. 05). 72 h after operation,the incidence of POCD was lower in the than that of A group and C group( P < 0. 05),A group the incidence of POCD was the lowest in the C group,followed by the the A group and the B group( P < 0. 05). Before operation,there was no statistical significance in serum TNF-a,IL-6,SOD or MDA level among the three groups( P > 0. 05). 24 h,72 h,and 1 week after operation,the levels of TNF-a,IL-6 and MDA were lower in the group B than in the A group and the C group( P < 0. 05),and the level of SOD was higher in the B group than in the A group and the C group( P <0. 05). The levels of IL-6,MDA and TNF-a were lower in the A group than in the C group( P < 0. 05),and SOD was higher in the A group than in the C group( P < 0. 05). Conclusion 0. 8 g/kg dexmedetomidine infusion and0. 5 g/kg dose can reduce the lung cancer patients,oxidative stress,inflammatory reaction,and reduce the postoperative incidence of POCD.
作者
黄大雪
舒华
任晓卉
HUANG Da-xue;SHU Hua;REN Xiao-hui(Neijiang Second People’s Hospital,Neijiang,Sichuan 641000,China)
出处
《临床肺科杂志》
2018年第1期156-160,共5页
Journal of Clinical Pulmonary Medicine
关键词
右美托咪定
肺癌根治手术
认知功能
炎症反应
氧化应激水平
dexmedetomidine
radical resection of lung cancer
cognitive function
inflammatory response
oxidative stress
作者简介
通信作者:舒华,Email:330792417@qq.com.
