摘要
癌因性疲乏是肺癌的常见并发症,高发于肺癌的治疗时期和转移阶段,严重降低患者的生活质量,影响到肺癌的治疗进展。据研究“三本二统”论中肺脾肾三脏是癌因性疲乏重要的发病机制。目前研究发现,线粒体能量代谢障碍与肺癌癌因性疲乏发病具有密切的联系。中医学中“肺失宣降、脾运失司、肾精失养”三脏功能异常,均会对线粒体能量代谢产生影响,采用清金保肺、培土调中、滋肾温阳疗法可以缓解癌因性疲乏症状,且改善线粒体能量代谢功能。因此,文章基于“三本二统”论及线粒体能量代谢障碍探讨肺癌癌因性疲乏机制,为治疗癌因性疲乏提供治疗思路。
Cancer-related fatigue is a common complication of lung cancer,occurring most frequently during treat-ment and during the metastatic stage.It significantly reduces patients’quality of life and hinders treatment progress.Research suggests that the lung,spleen,and kidney,three organs,are key mechanisms underlying cancer-related fa-tigue,according to the“Three Roots and Two Systems”theory.Current research has found a close link between mito-chondrial energy metabolism disorders and the onset of cancer-related fatigue in lung cancer.In Traditional Chinese Medicine,dysfunctional function of the three organs—lung failure to descend,spleen failure to transport,and kidney failure to nourish essence—all impacts mitochondrial energy metabolism.Therapies targeting the principles of“clearing the lungs and protecting the lungs,”“tonifying the middle and regulating the middle,”and“nourishing the kidneys and warming the Yang”can alleviate symptoms of cancer-related fatigue and improve mitochondrial energy metabolism.Therefore,this article explores the mechanisms underlying cancer-related fatigue in lung cancer based on the“Three Roots and Two Systems”theory and mitochondrial energy metabolism disorders,providing therapeutic strategies for treating cancer-related fatigue.
作者
李梦茜
李山山
齐琳芳
杨水苗
余雪汝
李晓丹
LI Mengqian;LI Shanshan;QI Iinfang;YANG Shuimiao;YU Xueru;LI Xiaodan(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300000,China)
出处
《中医药临床杂志》
2025年第9期1701-1705,共5页
Clinical Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(8210152432)
天津市卫生健康委员会中医中西医结合科研课题(2025186)。
关键词
三本二统
线粒体
癌因性疲乏
肺癌
Three Roots and Two Systems
Mitochondria
Cancer-related fatigue
Lung cancer
作者简介
李梦茜(2000-),女,2023级在读硕士。研究方向:中医内科学呼吸学方向的研究。E-mail:lmq0108@163.com;通信作者:李晓丹(1986-),女,副主任医师,硕士生导师。研究方向:中西医结合呼吸内科学的研究。E-mail:lixiaodan11223@163.com。
