摘要
目的探究乳腺癌前哨淋巴结(SLN)转移的相关影响因素,并探讨总结具体干预对策,以便能为阻止病情进展、优化治疗方案提供指导。方法回顾性分析乳腺癌SLN转移(35例)患者与未转移患者(50例)的病历资料,对乳腺癌SLN转移的相关影响因素进行单因素及多因素Logistic回归分析。结果乳腺癌SLN转移与未转移患者在年龄、体质量指数、有无吸烟史与饮酒史、是否绝经、原发肿瘤位置、分子分型、SLN个数、雌激素受体(ER)、孕激素受体(PR)方面,无统计学差异(P>0.05);乳腺癌SLN转移与未转移患者在肿瘤大小、病理分型、组织学分级、脉管是否浸润、人表皮生长因子受体-2(HER-2)、B超检查结果方面,存在统计学差异(P<0.05)。多因素Logistic回归分析显示,肿瘤大小[OR=6.127,95%CI=(2.021,18.575)]、脉管是否浸润[OR=2.628,95%CI=(1.067,6.472)]、HER-2[OR=2.714,95%CI=(1.051,7.005)]、组织学分级[OR=1.743,95%CI=(1.020,12.979)]、B超检查结果[OR=1.639,95%CI=(1.030,2.609)]是乳腺癌SLN转移的相关影响因素(P<0.05)。结论重视对乳腺癌SLN转移风险因素观察,并注重加强对患者影像学检查及肿瘤标志物检查,能够丰富临床对SLN转移状态的有效评估,为患者后续治疗提供更多参考依据。
Objective To investigate the relevant factors affecting sentinel lymph node(SLN)metastasis in breast cancer,and explore specific intervention strategies to provide guidance for preventing disease progression and optimizing treatment plans.Methods A retrospective analysis was conducted on the medical records of patients with SLN metastasis(35 cases)and those without metastasis(50 cases)in breast cancer.Univariate and multivariate Logistic regression analyses were performed on the related influencing factors of SLN metastasis in breast cancer.Results There were no statistically significant differences between patients with and without SLN metastasis in breast cancer in comparison of age,body mass index,smoking and drinking history,menopausal status,primary tumor location,molecular subtype,number of SLNs,estrogen receptor(ER),and progesterone receptor(PR)(P>0.05).There were statistical differences in tumor size,pathological classification,histological grading,vascular invasion,human epidermal growth factor receptor-2(HER-2),and B-ultrasound results between patients with and without SLN metastasis in breast cancer(P<0.05).Multivariate Logistic regression analysis revealed that tumor size[OR=6.127,95%CI=(2.021,18.575)],vascular invasion[OR=2.628,95%CI=(1.067,6.472)],HER-2[OR=2.714,95%CI=(1.051,7.005)],and histological grading[OR=1.743,95%CI=(1.020,12.979)],and B-ultrasound results[OR=1.639,95%CI=(1.030,2.609)]were identified as significant factors associated with SLN metastasis in breast cancer(P<0.05).Conclusion Paying attention to the risk factors for SLN metastasis in breast cancer and enhancing imaging examination and tumor marker tests for patients can enrich the clinical assessment of SLN metastasis status and provide more reference information for the subsequent treatment of patients.
作者
万媛君
WAN Yuan-jun(Department of Breast Traditional Chinese Medicine,The Second Affiliated Hospital of Nanchang University,Nanchang 330029,China)
出处
《中国现代药物应用》
2025年第19期43-46,共4页
Chinese Journal of Modern Drug Application
关键词
乳腺癌
前哨淋巴结转移
相关因素
对策研究
Breast cancer
Sentinel lymph node metastasis
Related factors
Countermeasures
