摘要
失眠是生活中常见的睡眠问题,严重影响患者的生活质量以及身体健康。厥阴失眠主要是指凌晨1点~3点易醒,醒后难以入睡。乌梅丸为治疗厥阴病之主方,张仲景最初用其治疗蛔厥,后世医家发现其在治疗厥阴失眠上亦有较好的疗效。本文采用RevMan5.4统计软件对乌梅丸治疗厥阴失眠的数据进行Meta分析,运用网络药理学-分子对接技术研究其潜在的作用机制,并对其作用机制进行总结分析,以期为失眠的治疗提供新的思路。结果表明,乌梅丸治疗厥阴失眠具有较好的效果,且优于常规西药治疗,主要涉及AGE-RAGE、Cytokine-cytokine receptor interaction、IL-17等相关神经及炎症信号通路。
Insomnia is a common sleep problem in life,which seriously affects the quality of life and health of patients.Jueyin insomnia mainly refers to waking up easily from 1 am to 3 am,and it is difficult to fall asleep after waking up.Wumei Pills is the main prescription for treating Jue Yin disease.Zhang Zhongjing first used it to treat syncope,and later doctors found that it also had a good effect on treating Jue Yin insomnia.In this paper,the Wumei Pills in the treatment of Jueyin insomnia were meta-analyzed by using RevMan5.4 statistical software,and its potential mechanism of action was studied by using network pharmacology grafting molecular docking technology,and the research on its mechanism of action was summarized and analyzed in order to provide new ideas for the treatment of insomnia.These results show that Wumei Pills has a good effect on Jue Yin insomnia,and it is superior to conventional western medicine treatment,mainly involving related nerve and inflammatory signal pathways such as AGE-RAGE,Cytokine-cytokine receptor interaction and IL-17.
作者
郭殿增
潘英会
魏箫箫
娄慧慧
庞爱梅
刘瑞霞
GUO Dianzeng;PAN Yinghui;WEI Xiaoxiao;LOU Huihui;PANG Aimei;LIU Ruixia(Jinan Children's Welfare Institute Rehabilitation Medicine,Jinan 250100,China;Shandong Vocational College of Special Education,Jinan 250014,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250013,China)
出处
《四川中医》
2025年第8期77-86,共10页
Journal of Sichuan of Traditional Chinese Medicine
基金
山东中医药发展计划(2019-168)。
关键词
乌梅丸
厥阴失眠
临床疗效
网络药理学-分子对接
机制
Wumei pills
Jueyin insomnia
Clinical efficacy
Network pharmacology-molecular docking
Mechanism
作者简介
第一作者:郭殿增,硕士,主治医师,研究方向:针灸与药物联合用药研究,E-mail:709044561@qq.com;通讯作者:庞爱梅,博士,主任技师,研究方向:中西医结合临床免疫与分子生物学研究,E-mail:pamfxy@163.com。
