摘要
代谢组学作为系统生物学的核心技术之一,近年来在环境科学领域得到了广泛应用,尤其在新污染物的识别和机制研究方面展现了重要潜力。通过高通量分析生物体内代谢产物的变化,代谢组学不仅能够揭示新污染物的暴露信息,还能为其生物效应提供详细的分子级别的证据。该文综述了代谢组学的基础理论、分析技术、数据处理方法及其在环境污染物研究中的具体应用。重点阐述了代谢组学在新污染物检测、特征代谢物发现、毒理机制研究、代谢途径解析和环境风险评估等领域的创新应用,以期为今后环境污染物研究提供系统的代谢组学框架,并为相关政策制定和环境风险管理提供科学依据。
Metabolomics,as one of the core technologies of systems biology,has been widely applied in the field of environ⁃mental science in recent years,especially showing significant potential in the identification and mechanism research of new pollutants.By analyzing changes in metabolic products within organisms through high-throughput methods,metabolomics can not only reveal exposure information of emerging contaminants but also provide detailed molecular-level evidence for their biological effects.This article reviews the basic theories of metabolomics,analytical techniques,data processing methods,and their specific applications in environmental pollutant research.It focuses on the innovative applications of metab⁃olomics in the detection of emerging contaminants,discovery of characteristic metabolites,toxicological mechanism research,metabolic pathway analysis,and environmental risk assessment.This article aims to provide a systematic metabolomic frame⁃work for future environmental pollutant research and to offer a scientific basis for policy-making and environmental risk management.
作者
游宪宇
任超琪
李留安
贺泽英
王济世
YOU Xianyu;REN Chaoqi;LI Liu’an;HE Zeying;WANG Jishi(Key Laboratory for Environmental Factors Control of Agro-product Quality Safety/National Reference Laboratory for Agricultural Testing(Ministry of Agriculture),Agro-environmental Protection Institute,Ministry of Agriculture and Rural Affairs,Tianjin 300191,China;College of Animal Science and Veterinary Medicine,Tianjin Agricultural University,Tianjin 300392,China)
出处
《环境科学与技术》
北大核心
2025年第8期90-102,共13页
Environmental Science & Technology
基金
中央级公益性科研院所基本科研业务费专项(2024-jbkyywf-wjs)。
关键词
代谢组学
环境污染物
新污染物
环境风险评估
metabolomics
environmental pollutants
emerging contaminants
environmental risk assessment
作者简介
游宪宇(2001-),男,硕士研究生,研究方向为污染物毒性分析,(电子信箱)1371210122@qq.com;通讯作者:王济世,贺泽英,(电子信箱)hezeying@caas.cn;通讯作者:王济世,(电子信箱)wangjishi@caas.cn。
