摘要
目的探讨小剂量5型磷酸二酯酶抑制剂(phosphodiesterase type 5 inhibitors,PDE-5)他达拉非在男性勃起功能障碍(erectile dysfunction,ED)治疗中的价值。方法选取2020年2月至2023年1月于宜春市人民医院确诊为ED的60例患者作为研究对象,采用随机数字表法分为两组,每组30例。对照组实施他达拉非按需治疗,观察组实施他达拉非持续治疗,比较两组临床疗效、不良反应发生率、睾酮[总睾酮(total testosterone,TT)、游离睾酮(free testosterone,FT)]、夜间阴茎胀大试验、临床指标[勃起功能国际问卷-5(international questionnaire on erectile function-5,IIEF-5)、性接触档案-Q3(sexual encounter profile-Q3,SEP-Q3)、勃起硬度分级评分(erection hardness score,EHS)评分]、阴茎硬度≥60%维持时间。结果观察组治疗总有效率为96.67%,高于对照组的73.33%(P<0.05);两组不良反应发生率比较差异无统计学意义;治疗后,观察组TT、FT水平均高于对照组(P<0.05);治疗后,观察组有效勃起次数多于对照组,阴茎平均张力大于对照组,平均勃起时间长于对照组(P<0.05)。治疗后,观察组IIEF-5、SEP-Q3、EHS评分均高于对照组(P<0.05)。治疗后,观察组阴茎头部、根部硬度≥60%维持时间均长于对照组(P<0.05)。结论他达拉非持续治疗ED临床疗效及安全性较高,可延长勃起时间,改善患者性生活质量。
Objective To explore the value of low-dose phosphodiesterase type 5 inhibitors(PDE-5)tadalafil in the treatment of male erectile dysfunction(ED).Methods 60 patients diagnosed with ED in Yichun People's Hospital from February 2020 to January 2023 were selected,and they were divided into two groups by random number table method,with 30 cases in each group.The control group was treated with tadalafil on demand,while the observation group was treated with tadalafil continuously.The clinical efficacy,incidence of adverse reactions,testosterone(total testosterone[TT],free testosterone,[FT]),nocturnal penile swelling test,clinical indicators(international questionnaire on erectile function-5[IIEF-5],sexual encounter profile-Q3[SEP-Q3],erection hardness score[EHS]),and maintenance time of penile hardness≥60%were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 73.33%in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.After treatment,the TT and FT in the observation group were higher than those in the control group(P<0.05).After treatment,the number of effective erections in the observation group was more than that in the control group,the average penile tension was greater than that in the control group,and the average erectile duration was longer than that in the control group(P<0.05).After treatment,the IIEF-EF score,SEP Q3 score and EHS score in the observation group were higher than those in the control group(P<0.05).After treatment,the maintenance time of penile head and root hardness≥60%in the observation group was longer than that in the control group(P<0.05).Conclusion Tadalafil has high clinical efficacy and safety in the continuous treatment of ED,can prolong erection time,and improve sexual quality of life.
作者
王浩林
刘世兰
林鹏修
WANG Haolin;LIU Shilan;LIN Pengxiu(Department of Urology,Yichun People's Hospital,Yichun,Jiangxi,336000,China;Department of Urology,Yichun Vocational and Technical College Affiliated Hospital,Yichun,Jiangxi,336000,China)
出处
《当代医学》
2025年第4期44-48,共5页
Contemporary Medicine
