摘要
目的:探究九香虫汤治疗对ED患者阴茎勃起硬度、IIEF-5及睾酮水平的影响。方法:选取2018年7月至2020年1月诊治的120例ED患者进行研究,根据随机数字表法分为观察组(65例)和对照组(55例),对照组口服西地那非,观察组在对照组基础上温服九香虫汤,治疗8周,随访6个月,观察两组中医证候积分、临床疗效、阴茎勃起硬度、IIEF-5、睾酮水平及不良反应。结果:中医证候积分:与治疗前比较,治疗后观察组[(9.81±0.61)分vs(17.63±1.16)分]和对照组[(13.18±0.75)分vs(17.56±1.23)分]均显著降低(P<0.05),而且观察组得分比对照组更低(P<0.01)。观察组治疗总有效率显著高于对照组[92.31%(60/65)vs 80.00%(44/55),(P<0.05)]。勃起硬度评分(EHS):与治疗前比较,治疗后观察组[(4.21±0.55)分vs(2.55±0.73)分]和对照组[(3.14±0.54)分vs(2.61±0.73)分]均显著提高(P<0.05),且观察组显著高于对照组(P<0.01)。IIEF-5:与治疗前比较,治疗后观察组[(18.58±5.26)分vs(12.00±4.68)分]和对照组[(15.29±4.70)分vs(11.94±4.54)分]均显著提高(P<0.05),且观察组显著高于对照组(P<0.01)。睾酮:与治疗前比较,治疗后观察组[(13.27±4.21)nmol/Lvs(9.43±4.31)nmol/L]和对照组[(10.74±4.15)nmol/Lvs(9.01±4.72)nmol/L]均显著提高(P<0.05),且观察组显著高于对照组(P<0.01)。两组患者不良反应发生率比较,差异无统计学意义[6.15%(4/65)vs3.64%(2/55),(P=0.834)]。结论:九香虫汤治疗ED患者疗效较好,可显著改善临床症状,增加阴茎勃起硬度和睾酮水平,修复勃起功能,且不良反应较小。
Objective:To explore the effect of Coridius Decoction on penile erection hardness,IIEF-5 scores and the testosterone level in ED patients.Methods:We selected 120 ED patients diagnosed and treated in our hospital between July 2018 and January 2020 and,using the random number table,divided them into a control(n=55)and an observation(n=65),the former treated with oral sildenafil and the latter with warm Coridius Decoction in addition,both for 8 weeks and followed up for 6 months.We compared the TCM syndrome scores,clinical effects,penile erection hardness,IIEF-5 scores,testosterone(T)level and adverse reactions between the two groups of patients.Results:The TCM syndrome score,compared with the baseline,was significantly decreased in the observation(9.81±0.61 vs 17.63±1.16,P<0.05)and the control group(17.56±1.23 vs 13.18±0.75,P<0.05)after treatment,even lower in the former than in the latter group(P<0.01).The total therapeutic effectiveness rate was markedly higher in the observation group than in the control(92.31%[60/65]vs 80.00%[44/55],P<0.05).After medication,the erection hardness score(EHS)was dramatically higher than the baseline in the observation(4.21±0.55 vs 2.55±0.73,P<0.01)and the control group(3.14±0.54 vs 2.61±0.73,P<0.01),and so were the IIEF-5 score(18.58±5.26 vs 12.00±4.68,P<0.05 and 15.29±4.70 vs 11.94±5.54,P<0.05)and the T level([13.27±4.21]vs[9.43±4.31]nmol/L,P<0.05 and[10.74±4.15]vs[9.01±4.72]nmol/L,P<0.05),both even higher in the former than in the latter group(P<0.01).There were no statistically significant differences in the incidence rates of adverse reactions between the observation and control groups(6.15%[4/65]vs 3.64%[2/55],P=0.834).Conclusion:Coridius Decoction is safe and effective for the treatment of ED,which can significantly improve the clinical symptoms,increase penile erectile hardness and the T level,and repair the erectile function of the patient.
作者
陈慰填
周文彬
古宇能
洪志明
王全
曾杨玲
黄忠旺
CHEN Wei-tian;ZHOU Wen-bin;GU Yu-neng;HONG Zhi-ming;WANG Quan;ZENG Yang-ling;HUANG Zhong-wang(Department of Andrology,Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen,Guangdong 518033,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2020年第12期1124-1128,共5页
National Journal of Andrology
基金
深圳市中医重点专科建设项目(2019-2023年)
广东省中医药局“十三五”中医重点专科建设项目
作者简介
陈慰填(1980-),男,广东揭阳市人,硕士研究生,副主任中医师,从事中医男科方向研究;通讯作者:周文彬,Email:zwb1054@126.com
