摘要
目的通过数据挖掘和网络药理学方法探究陈捷医生治疗小儿功能性消化不良(functional dyspepsia,FD)的用药规律及其核心药组的潜在作用机制。方法收集2020年1月至2024年12月温州医科大学附属第二医院陈捷医生门诊治疗小儿FD的处方,建立处方数据库。应用Excel 2019和SPSS软件对纳入处方的药物性味、归经和频次进行统计,并进行关联规则分析和聚类分析。利用网络药理学方法探究核心药组的潜在作用机制。结果共纳入603张处方,涉及160味中药,累计用药频次达5012次。其中用药性味以温性、甘味为主,归经以脾经、胃经、肺经为主,关联规则和聚类分析获得核心药组为“麸炒白术–茯苓–陈皮”。对核心药组进行网络药理学分析,发现其主要成分有柚皮素、白术内酯Ⅰ、苍术酮、常春藤皂苷元等,核心基因有AKT1、TNF、IL-6、ESR1、IL-1β等。主要富集通路为脂质和动脉粥样硬化、晚期糖基化终末产物–晚期糖基化终末产物受体信号通路、癌症通路等。结论陈捷医生治疗小儿FD的用药以健脾益气、理气化湿为主。核心药组“麸炒白术–茯苓–陈皮”通过多成分、多靶点、多通路发挥作用。
Objective The medication pattern of doctor Chen Jie in treating functional dyspepsia(FD)in children and the potential mechanism of action of core drug group were explored through data mining and network pharmacology methods.Methods The prescriptions for pediatric FD treated by doctor Chen Jie in the outpatient department of Second Affiliated Hospital of Wenzhou Medical University from January 2020 to December 2024 were collected to establish a prescription database.Excel 2019 and SPSS software were applied to statistically analyze the nature,taste,meridian tropism and frequency of drugs included in the prescriptions,and association rule analysis and cluster analysis were conducted.The potential mechanism of action of the core drug group was explored by using the network pharmacology method.Results A total of 603 prescriptions were included,involving 160 kinds of drugs,with a cumulative frequency of medication reaching 5012 times.Among them,the medicinal nature and flavour were mainly warm and sweet,and channel tropism were mainly the spleen,stomach and lung meridians.The core drug group obtained through association rules and cluster analysis was“Fuchao Baizhu-Fuling-Chenpi”.Network pharmacological analysis was conducted on the core drug group,and it was found that its main components included naringenin,atractylenolideⅠ,atractylone,and hederagenin,as well as core genes such as AKT1,TNF,IL-6,ESR1,and IL-1β.The main enrichment pathways were lipids and atherosclerosis,advanced glycation end product-advanced glycation end product receptor signaling pathway,cancer pathway,etc..Conclusion Doctor Chen Jie’s medication for treating FD in children mainly focuses on invigorating spleen and replenishing qi,regulating qi-flowing for eliminating dampness.The core drug group,“Fuchao Baizhu-Fuling-Chenpi”,exerts its effects through multiple components,multiple targets and multiple pathways.
作者
陈冬清
伍一炜
范佳萍
朱寅荻
陈捷
CHEN Dongqing;WU Yiwei;FAN Jiaping;ZHU Yindi;CHEN Jie(Department of Pharmacy,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325024,Zhejiang,China;College of Chinese Medicine,Wenzhou Medical University,Wenzhou 325035,Zhejiang,China;Department of Traditional Chinese Medicine,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325024,Zhejiang,China)
出处
《中国现代医生》
2025年第22期63-68,共6页
China Modern Doctor
基金
浙江省温州市名中医陈捷传承工作室(温卫发[2015]119号)。
作者简介
通信作者:陈捷,电子信箱:yuyingchenjie@163.com。
