摘要
骨质疏松症(Osteoporosis,OP)是常见临床疾病之一,其机制为骨稳态被破坏,破骨细胞的骨吸收作用大于成骨细胞的骨形成作用,从而导致骨量减少、骨脆性增加,出现骨痛、乏力、脊柱变形、骨折等临床表现。临床常见抗OP药物存在用药周期长、费用高、长期疗效并不显著,以及诸多药物不良反应等缺点,此外,随着人口老龄化日益加剧,OP患病率也在骤升,现已成为重要的社会公共健康问题,因此,亟待寻找新的替代治疗药物。中医药防治OP由来已久,疗效确切,且具有不良反应小、作用位点多、来源广等优点。巴戟天作为我国四大南药之一,长于补肝肾、强筋骨、祛风湿等,历来被用作治疗“骨痿”“骨痹”等病,近年来大量研究证实其防治OP有确切疗效,并通过药理学研究发现巴戟天的具体活性成分主要为糖类、环烯醚萜苷类、蒽醌类三大类,从雌激素受体机制、骨代谢相关细胞因子机制、氧化应激机制及调节信号通路机制四个方向防治OP。为探讨巴戟天有效活性成分防治OP的具体作用机制,发掘更有效的抗OP药物,文章详细总结了近些年巴戟天有效活性成分防治OP文献,以期为临床提供更好的用药指导。
Osteoporosis is one of the common clinical diseases,its mechanism is the disruption of bone homeostasis,osteoclast bone resorption is greater than the bone formation of osteoblasts,which leads to a reduction in the amount of bone mass,and the increase of bone fragility,with a series of bone pain,fatigue,spinal deformity,bone fracture and other clinical manifestations.Common clinical anti-osteoporosis drugs have shortcomings such as long drug use cycle,high cost,insignificant long-term efficacy,and many adverse drug reactions.In addition,with the increasing aging of the population,the prevalence of osteoporosis is also rising rapidly,and it has become an important social public health problem.Therefore,it is urgent to find new alternative therapeutic drugs.Traditional Chinese medicine has been used for preventing and treating osteoporosis for a long time,and has the advantages of low toxicity,multiple action sites and wide range of sources.As one of the four major southern medicinals in China,Bajitian(Radix Morindae Officinalis)has long been known for its efficacy of tonifying the liver and kidney,strengthening the muscles and bones,dispelling wind and dampness,etc.It has always been utilized as a treatment for“bone impotence”“bone paralysis”and other disorders.In recent years,a large number of studies have confirmed that it has a definite effect on the prevention and treatment of osteoporosis,and pharmacological studies have found that the specific active ingredients of Bajitian are mainly carbohydrates,iterpenoid glycosides,and anthraquinones,which prevent and treat osteoporosis from four directions:estrogen receptor mechanism,bone metabolise-related cytokine mechanism,oxidative stress mechanism,and regulatory signaling pathway mechanism.To explore the specific mechanism of action of the effective active ingredients of Bajitian in the prevention and treatment of osteoporosis and discover more effective anti-osteoporosis drugs,the author has summarized the relevant literature on the effective active ingredients of Bajitian in the prevention and treatment of osteoporosis in details in recent years,aiming to provide better drug guidance for the clinical application.
出处
《中医临床研究》
2025年第9期64-69,共6页
Clinical Journal Of Chinese Medicine
关键词
中医
巴戟天
中药单体
骨代谢
骨质疏松症
Traditional Chinese medicine
Bajitian
Chinese medicine monomer
Bone metabolism
Osteoporosis
作者简介
通讯作者:胡一梅。
