摘要
目的 观察温胆汤加减方治疗心胆气虚型失眠的临床疗效及远期疗效。方法 采用随机数字表法将北京市昌平区中西医结合医院2023年4月-2024年5月门诊的心胆气虚型失眠患者63例分为治疗组31例和对照组32例,治疗组剔除1例,对照组剔除2例,对照组接受奥沙西泮治疗,治疗组接受温胆汤加减方治疗,2组均治疗4周。比较2组治疗后临床疗效、睡眠质量(PSQI评分)、中医证候积分、不良反应,随访2个月比较复发率。结果 治疗4周后,治疗组总有效率更高(P<0.05);2组PSQI评分、中医证候积分均低于治疗前(P<0.05),治疗组均低于对照组(P<0.05);2组不良反应低。复发率治疗组更低(P<0.05)。结论 温胆汤加减方治疗心胆气虚型失眠可提高治疗效果,改善睡眠质量和中医证候,其远期疗效稳定,治疗安全性较高,值得推广。
Objective To observe the clinical efficacy and long-term effect of modified Wendan Decoction in the treatment of insomnia with the heart-gallbladder qi deficiency syndrome.Methods A total of 63 insomnia patients with the heart-gallbladder qi deficiency syndrome were collected from the Beijing Changping Hospital of Integrated Chinese and Western Medicine from April 2023 to May 2024.They were randomly divided into a treatment group(31 cases)and a control group(32 cases),with one case excluded from the treatment group,and two cases excluded from the control group.The control group received a treatment with oxazepam,while the treatment group received modified Wendan Decoction.After 4 weeks of treatment,the clinical efficacy,sleep quality(PSQI scores),traditional Chinese medicine syndrome scores,and adverse reactions were compared between the two groups before and after treatment,and the recurrence rate was compared between the two groups after a two-month follow-up.Results After treatment,the total effective rate was higher in the treatment group(P<0.05).The PSQI scores and TCM syndrome scores of both groups were lower than before treatment,and the scores were both lower in the treatment group than those in the control group(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).The follow-up for two months showed that the recurrence rate was lower in the treatment group(P<0.05).Conclusion Modified Wendan Decoction can improve the therapeutic effect,improve sleep quality and TCM syndromes in the treatment of insomnia with the heart-gallbladder qi deficiency syndrome,and its long-term efficacy is stable and the treatment safety is high,which is worth promoting.
作者
张忠
张国玲
李子全
甄丽芳
刘士玲
包思
ZHANG Zhong;ZHANG Guoling;LI Ziquan;ZHEN Lifang;LIU Shiling;BAO Si(Beijing Changping Hospital of Integrated Chinese and Western Medicine,Beijing 102208,China;Beijing Tibetan Hospital,Beijing 100029,China)
出处
《吉林中医药》
2025年第6期680-683,共4页
Jilin Journal of Chinese Medicine
基金
世界中联中医疗养研究专业委员会中医疗养学科研立项项目(2023ZYLY020)
北京市中医药科技发展资金项目课题(BJZYYB-2023-48)。
关键词
失眠
不寐
心胆气虚
温胆汤加减方
奥沙西泮
insomnia
wakefulness
heart-gallbladder qi deficiency
modified Wendan Decoction
oxazepam
作者简介
张忠(1977-),男,副主任医师,主要从事中医经典方的临床应用。
