摘要
目的:研究不明原因复发性流产(URSA)患者维生素D(VD)水平与Th1(IL-2、TNF-α、IFN-γ)/Th2(IL-4、IL-6、IL-10)水平以及妊娠结局的相关性。方法:回顾性分析佛山复星禅诚医院2023年1月—2024年12月60例URSA患者的临床资料(实验组),另选取该院近2年60例健康妇女的临床资料(对照组);于孕前接受VD、Th1/Th2水平检测,根据URSA患者妊娠结局再分为两组,即妊娠成功组(n=51),妊娠失败组(n=9),经Spearman法分析VD、Th1/Th2水平与妊娠结局的相关性。结果:实验组VD、IL-4、IL-6、IL-10低于对照组;IL-2、TNF-α、IFN-γ高于对照组(P<0.05)。妊娠失败组VD、IL-4、IL-6、IL-10低于妊娠成功组;IL-2、TNF-α、IFN-γ高于妊娠成功组(P<0.05),经Spearman法分析,URSA患者妊娠结局与VD、IL-4、IL-10呈负相关,与IL-2、TNF-α、IFN-γ呈正相关(P<0.05)。同时,经ROC曲线分析,各指标预测URSA患者妊娠结局的AUC均在0.8以上。结论:URSA再次妊娠患者VD、Th1/Th2水平与妊娠结局密切相关。
Objective:To investigate the correlation between vitamin D(VD)levels and Th1(IL-2,TNF-α,IFN-γ)/Th2(IL-4,IL-6,IL-10)levels and pregnancy outcomes in patients with unexplained recurrent abortion(URSA).Methods:The clinical data of 60 patients with URSA in Foshan Fuxing Chancheng Hospital from January 2023 to December 2024 were retrospectively analyzed(experimental group),and the clinical data of 60 healthy women in the past 2 years were selected(control group).VD and Th1/Th2 levels were detected before pregnancy,and URSA patients were further divided into two groups according to pregnancy outcome,namely,pregnancy success group(n=51)and pregnancy failure group(n=9).The correlation between VD and Th1/Th2 levels and pregnancy outcome was analyzed by Spearman method.Results:VD,IL-4,IL-6 and IL-10 in experimental group were lower than those in control group.IL-2,TNF-αand IFN-γwere higher than those in control group(P<0.05).The levels of VD,IL-4,IL-6 and IL-10 in the failed pregnancy group were lower than those in the successful pregnancy group.IL-2,TNF-αand IFN-γwere higher than those in the successful pregnancy group(P<0.05).Spearman analysis showed that the pregnancy outcome of URSA patients was negatively correlated with VD,IL-4 and IL-10,and positively correlated with IL-2,TNF-αand IFN-γ(P<0.05).At the same time,through ROC curve analysis,the AUC of pregnancy outcome predicted by each index of URSA patients was above 0.8.Conclusion:VD and Th1/Th2 levels are closely related to pregnancy outcomes in URSA patients with second pregnancy.
作者
宋玉花
梁娇
曾燕飞
Song Yuhua(Foshan Fuxing Chancheng Hospital,Foshan 528000)
出处
《黑龙江医药》
2025年第3期562-565,共4页
Heilongjiang Medicine journal
基金
2022年佛山市自筹经费类科技计划项目(项目编号:2220001005161-03)。
作者简介
宋玉花(1980年12月出生),女,汉族,河南郑州人,本科,副主任医师,研究方向:妇产科临床。
