摘要
目的探究多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清促性腺激素峰抑制因子(gonadotropin peak inhibitory factor,GnSAF)、鸢尾素(irisin)和肽素(copeptin)水平与临床指标的相关性,以及GnSAF、irisin、copeptin水平对PCOS妊娠结局的预测价值。方法选取2021年10月至2023年6月大冶市人民医院收治的118例PCOS患者作为研究对象,根据是否临床妊娠成功分为失败组和成功组。收集患者的临床指标[促卵泡生成素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、孕酮(progesterone,P)、睾酮(testosterone,T)、雌二醇(estradiol,E_(2))],检测血清GnSAF、irisin、copeptin水平。采用Pearson相关分析患者GnSAF、irisin、copeptin与临床指标的相关性,绘制受试者工作特征(receiver operating characteristic,ROC)曲线并计算曲线下面积(area under curve,AUC),分析GnSAF、irisin、copeptin水平单独及联合检测对PCOS患者临床妊娠失败的预测价值。结果118例PCOS患者经随访及阴道超声检查证实临床妊娠成功26例(22.03%),失败92例(77.97%)。失败组FSH、GnSAF、copeptin水平均低于成功组,LH、T、irisin水平均高于成功组,差异有统计学意义(P<0.05)。Pearson相关分析显示,血清GnSAF与FSH呈正相关(r>0,P<0.05),与LH、T均呈负相关(r<0,P<0.05);血清irisin与FSH呈负相关(r<0,P<0.05),与LH、T均呈正相关(r>0,P<0.05);血清copeptin与FSH呈正相关(r>0,P<0.05),与LH、T均呈负相关(r<0,P<0.05)。ROC曲线显示,GnSAF、irisin、copeptin三者联合预测PCOS患者妊娠失败的AUC为0.803,灵敏度和特异度为88.04%和80.77%,预测价值高于各指标单独预测。结论血清GnSAF、irisin、copeptin水平与PCOS患者FSH、LH、T等临床指标水平及临床妊娠失败具有相关性,检测血清GnSAF、irisin、copeptin水平可预测患者PCOS患者的妊娠结局。
Objective To explore the correlation of serum gonadotropin peak inhibitory factor(GnSAF),irisin,copeptin levels with clinical indicators in patients with polycystic ovary syndrome(PCOS),and the predictive value of GnSAF,irisin and copeptin in pregnancy outcome of PCOS.Methods A total of 118 patients with PCOS admitted to Daye People's Hospital from October 2021 to June 2023 were selected as the research subjects,they were divided into the failed group and the successful group based on whether the clinical pregnancy was successful or not.Clinical indicators of the patients(follicle-stimulating hormone[FSH],luteinizing hormone[LH],progesterone[P],testosterone[T],estradiol[E_(2)])were collected,serum GnSAF,irisin and copeptin levels were detected.Pearson correlation analysis was used to analyze the relationship between GnSAF,irisin,copeptin and clinical indicators,the receiver operating characteristic(ROC)curve was plotted and the area under the curve(AUC)was calculated,and the value of GnSAF,irisin,copeptin levels alone and in combination in predicting clinical pregnancy failure in PCOS patients was analyzed.Results In 118 patients with PCOS,clinical pregnancy was confirmed by follow-up and vaginal ultrasonography in 26 cases(22.03%)of success and 92 cases(77.97%)of failure.The levels of FSH,GnSAF and copeptin in the failed group were lower than those in the successful group,and the levels of LH,T and irisin were higher than those in the successful group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum level of GnSAF was positively correlated with FSH(r>0,P<0.05),and negatively correlated with LH and T(r<0,P<0.05);serum irisin was negatively correlated with FSH(r<0,P<0.05),and positively correlated with LH and T(r>0,P<0.05);serum copeptin was positively correlated with FSH(r>0,P<0.05),and negatively correlated with LH and T(r<0,P<0.05).The ROC curve showed that the AUC of GnSAF,irisin and copeptin in predicting pregnancy failure in PCOS patients was 0.803,the sensitivity and specificity were 88.04%and 80.77%respectively,and the combined prediction value was higher than that of each indicator alone.Conclusion Serum GnSAF,irisin and copeptin levels are correlated with the levels of FSH,LH,T and other clinical indicators as well as clinical pregnancy failure in PCOS patients,detection of serum GnSAF,irisin and copeptin levels can predict the pregnancy outcome of PCOS patients.
作者
曹党恩
鲁霞
CAO Dang'en;LU Xia(Department of Obstetrics and Gynecology,Daye People's Hospital,Daye,Hubei,435100,China)
出处
《当代医学》
2025年第3期82-85,共4页
Contemporary Medicine
作者简介
通信作者:鲁霞,E-mail:109415011@qq.com。
