摘要
目的:研究右佐匹克隆联合黛力新治疗失眠患者对睡眠质量的影响。方法:选取2021年3月至2022年3月福州市长乐区第二医院收治的失眠患者86例作为研究对象,按照数字编号信封法随机分为对照组(n=41)和观察组(n=45)。对照组早上中午各口服10 mg黛力新,观察组在对照组基础上睡前口服3 mg右佐匹克隆,2组均连续治疗8周。比较2组治疗前后睡眠质量[匹兹堡睡眠质量指数量表(PSQI)]、生命质量[生命质量调查表(SF-36)]、不良情绪[汉密尔顿抑郁量表(HAMD)]、日间嗜睡情况[Epworth嗜睡量表(ESS)],并比较2组疗效和不良反应发生率。结果:治疗后,观察组PSQI评分低于对照组,而SF-36评分则高于对照组,差异有统计学意义(P<0.05);同时,观察组HAMD、ESS评分均低于对照组,差异有统计学意义(P<0.05);与对照组总有效率75.61%比较,观察组93.33%显著更高,差异有统计学意义(P<0.05);与对照组不良反应21.95%比较,观察组6.67%显著更低,差异有统计学意义(P<0.05)。结论:右佐匹克隆联合黛力新治疗失眠患者,能有效提高睡眠质量和生命质量,有利于改善患者不良情绪和日间嗜睡情况,疗效显著,安全性高。
Objective:To study the effect of eszopiclone combined with doxepin on sleep quality in insomnia patients.Methods:A total of 86 insomnia patients treated at the Second Hospital of Changle District,Fuzhou,from March 2021 to March 2022 were selected as the study participants.They were randomly divided into a control group(n=41)and an observation group(n=45)using a digital envelope method.The control group received 10 mg of doxepin orally in the morning and at noon,while the observation group received 3 mg of eszopiclone orally before bedtime in addition to the doxepin.Both groups were treated for 8 weeks.Sleep quality was evaluated using the Pittsburgh Sleep Quality Index(PSQI),quality of life was assessed using the SF-36 Health Survey,negative emotions were evaluated using the Hamilton Depression Rating Scale(HAMD),daytime sleepiness was assessed using the Epworth Sleepiness Scale(ESS),and treatment efficacy and the incidence of adverse reactions were compared between the two groups.Results:After treatment,the observation group had significantly lower PSQI scores and higher SF-36 scores compared to the control group,with statistically significant differences(P<0.05).The observation group also had significantly lower HAMD and ESS scores compared to the control group,with statistically significant differences(P<0.05).The total effective rate in the observation group(93.33%)was significantly higher than that in the control group(75.61%)with a statistically significant difference(P<0.05).The incidence of adverse reactions in the observation group(6.67%)was significantly lower than that in the control group(21.95%),with a statistically significant difference(P<0.05).Conclusion:Eszopiclone combined with doxepin is effective in improving sleep quality and quality of life in insomnia patients,helping to alleviate negative emotions and daytime sleepiness.It is highly effective with good safety.
作者
陈华
许其友
CHEN Hua;XU Qiyou(Second Hospital of Changle District,Fuzhou 350211,China)
出处
《世界睡眠医学杂志》
2025年第3期518-521,共4页
World Journal of Sleep Medicine
作者简介
陈华(1989.11-),女,本科,主管药师,研究方向:药学,E-mail:chenchenhuahua2022@163.com;通信作者:许其友(1972.12-),本科,副主任药师,研究方向:药学,E-mail:184915466@qq.com。
